OTS186935 hydrochloride||-陌孚医药/Medlife

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OTS186935 hydrochloride

目录号: PL15050 纯度: ≥99%

商品编号	规格	价格	会员价
PL15050-5mg	5mg	¥4821.00	请登录
PL15050-10mg	10mg	¥8036.00	请登录
PL15050-50mg	50mg	¥22501.00	请登录
PL15050-100mg	100mg	¥31341.00	请登录
PL15050-200mg	200mg	询价	询价
PL15050-500mg	500mg	询价	询价
PL15050-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5545.00	请登录

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中文名称	OTS186935 hydrochloride
英文名称	OTS186935 hydrochloride
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	OTS186935 hydrochloride 是一种有效的蛋白甲基转移酶 SUV39H2 抑制剂，IC₅₀ 值为 6.49 nM。OTS186935 hydrochloride 对小鼠异种移植模型的肿瘤生长有明显的抑制作用，且无明显毒性。OTS193320 hydrochloride 调节癌细胞中 γ-H2AX 的产生。
生物活性	OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC 50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells.
性状	Solid
IC50 & Target[1][2]	IC50: 6.49 nM (SUV39H2)
体外研究(In Vitro)	OTS186935 hydrochloride inhibits A549 cell growth with an IC50 of 0.67 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Vougiouklakis T, et al. Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX. Oncotarget. 2018 Aug 7;9(61):31820-31831.

溶解度数据	In Vitro: H₂O : 50 mg/mL (95.73 mM; Need ultrasonic)DMSO : 25 mg/mL (47.86 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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