您当前的位置：

EPZ004777

目录号: PL15055 纯度: ≥98%

EPZ004777 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。

CAS No. :1338466-77-5

商品编号	规格	价格	会员价
PL15055-5mg	5mg	¥4018.00	请登录
PL15055-10mg	10mg	¥7232.00	请登录
PL15055-25mg	25mg	¥14465.00	请登录
PL15055-50mg	50mg	¥23144.00	请登录
PL15055-100mg	100mg	询价	询价
PL15055-200mg	200mg	询价	询价
PL15055-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4773.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	EPZ004777
中文别名	EPZ004777 抑制剂
英文名称	EPZ004777
英文别名	1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea;EPZ004777;0QK;EPZ-004777;S7032;7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine;EPZ 004777;7-{5-[(3-{[(4-Tert-Butylphenyl)carbamoyl]amino}propyl)(Propan-2-Yl)amino]-5-Deoxy-Beta-D-Ribofuranosyl}-7h-Pyrrolo[2,3-D]pyrimidin-4-Amine;WXRGFPHDRFQODR-ICLZECGLSA-N;GTPL7377;C28H41N7O4;BDBM50396023;s7353;Daclatasvir (BMS79;1-[3-[[(2R,3S,4R,5R)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-
Cas No.	1338466-77-5
分子式	C₂₈H₄₁N₇O₄
分子量	539.67
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	EPZ004777 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。

产品详情	EPZ004777 是一种有效的选择性 DOT1L 抑制剂，IC₅₀ 为 0.4 nM。
生物活性	EPZ004777 is a potent, selective DOT1L inhibitor with an IC 50 of 0.4 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 0.4 nM (DOT1L)
体外研究(In Vitro)	EPZ004777 demonstrates potent, concentration-dependent inhibition of DOT1L enzyme activity with an IC50 of 400±100 pM. EPZ004777 displays remarkable selectivity for inhibition of DOT1L over other HMTs(PRMT5, 521±137 nM; others, >50 μM). The effect of extended EPZ004777 treatment is remarkably specific for the MLL -rearranged cell lines. The number of viable MV4-11 and MOLM-13 cells is dramatically reduced by EPZ004777, whereas the growth of Jurkat cells is unaffected. A small population of MV4-11 cells remain viable in the presence of EPZ004777, but their number remain constant when growth curves are tracked over longer periods indicating that they have ceased to divide. The proliferation of MLL-AF9-transformed cells is strongly inhibited by EPZ004777 at concentrations of 3 μM or greater. EPZ004777 selectively inhibits proliferation of MLL-AF10 and CALM-AF1
体内研究(In Vivo)	EPZ004777 is well tolerated and no overt toxicity is observed. Complete blood count analysis after 14 days of continuous exposure to EPZ004777 revealed a statistically significant increase in the total white blood cell count, which resulted from an increase in neutrophils, monocytes, and lymphocytes. EPZ004777 (50, 100, or 150 mg/mL) administration is well tolerated, and no significant weight loss is observed. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65. [2]. Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.

溶解度数据	In Vitro: DMSO : 80 mg/mL (148.24 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Daigle SR, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65.
[2]. Chen L, et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

EPZ004777

相关产品

The molarity calculator equation

The dilution calculator equation