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PR5-LL-CM01

目录号: PL15010 纯度: ≥98%

PR5-LL-CM01 是一种有效的 (PRMT5) 抑制剂 (IC50= 7.5 μM)。PR5-LL-CM01 具有抗肿瘤活性。

CAS No. :1005307-86-7

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中文名称	PR5-LL-CM01
英文名称	PR5-LL-CM01
英文别名	1H-Pyrazolo[3,4-d]pyrimidine-4,6-diamine, N6-[2-(dimethylamino)ethyl]-N4-(3,4-dimethylphenyl)-1-phenyl-;N6-(2-Dimethylamino-ethyl)-N4-(3,4-dimethyl-phenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine;N~6~-[2-(dimethylamino)ethyl]-N~4~-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine;N6-(2-(dimethylamino)ethyl)-N4-(3,4-dimethylphenyl)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine-4,6;PR5-LL-CM01
Cas No.	1005307-86-7
分子式	C₂₃H₂₇N₇
分子量	401.51
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
详情描述	PR5-LL-CM01 是一种有效的 (PRMT5) 抑制剂 (IC50= 7.5 μM)。PR5-LL-CM01 具有抗肿瘤活性。

产品详情	PR5-LL-CM01 是一种有效的 (PRMT5) 抑制剂 (IC₅₀= 7.5 μM)。PR5-LL-CM01 具有抗肿瘤活性。
生物活性	PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC 50 = 7.5 μM). Anti-tumor activies.
性状	Solid
体外研究(In Vitro)	PR5-LL-CM01 has a range of IC50 at 2-4 μM in PDAC cells (PANC1, MiaPaCa2 and AsPC1, and a range of IC50 at 10-11 μM in CRC cells (HT29, HCT116 and DLD1). PR5-LL-CM01 has higher efficacy to specifically inhibit cancer cells and demonstrated low toxicity in normal cells. PR5-LL-CM01 strongly inhibited colony forming ability in both PANC1 and HT29 cells. PR5-LL-CM01 inhibits NF-κB activation and its target gene expression in PDAC and CRC cells. PR5-LL-CM01 (0-15 μM) dramatically decreases TNFα and IL8 expression in both PANC1 and HT29 cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	PR5-LL-CM01 (20mg/kg; i.p.; 3 times per week) displays significant anti-tumor effect. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 weeks old Male NSG mice (bearing PANC1 or HT2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8(25):39963-39977.

溶解度数据	In Vitro: DMSO : 11.11 mg/mL (27.67 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 80°C)配制储备液

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[1]. Prabhu L, et al. Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. Oncotarget. 2017;8(25):39963-39977.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

PR5-LL-CM01

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