ZLD1039 is a potent, highly selective, and orally bioavailable EZH2 inhibitor. ZLD1039 shows potent and concentration-dependent inhibition of PRC2 enzymatic activity against EZH2 wild-type as well as Y641F, and A677G mutant enzymes with IC 50 values of 5.6, 15, and 4.0?nM, respectively. ZLD1039 inhibits breast tumor growth and metastasis.
性状
Solid
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献
[1]. Xuejiao Song, et al. Selective inhibition of EZH2 by ZLD1039 blocks H3K27methylation and leads to potent anti-tumor activity in breast cancer. Sci Rep. 2016; 6: 20864.
溶解度数据
In Vitro: DMSO : 9.09 mg/mL (14.83 mM; ultrasonic and adjust pH to 3 with 1M HCl)配制储备液