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ICAM-1-IN-1

目录号: PL14851 纯度: ≥99%

ICAM-1-IN-1 是有效，选择性的 E-selectin 和 ICAM-1 抑制剂，IC50值分别为7和5 nM。

CAS No. :251994-14-6

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中文名称	ICAM-1-IN-1
英文名称	ICAM-1-IN-1
英文别名	Thieno[2,3-c]pyridine-2-carboxamide, 4-(4-bromophenoxy)-N-methyl-;CAM-IN-1;ICAM-1-IN-1;4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide;BDBM50105180;4-(4-Bromo-phenoxy)-thieno[2,3-c]pyridine-2-carboxylic acid methylamide
Cas No.	251994-14-6
分子式	C₁₅H₁₁BrN₂O₂S
分子量	363.23
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	ICAM-1-IN-1 是有效，选择性的 E-selectin 和 ICAM-1 抑制剂，IC50值分别为7和5 nM。

产品详情	ICAM-1-IN-1 是有效，选择性的 E-selectin 和 ICAM-1 抑制剂，IC₅₀值分别为7和5 nM。
生物活性	ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin and ICAM-1 with IC 50 values of 7 and 5 nM, respectively.
性状	Solid
IC50 & Target[1][2]	IC50: 7 nM (E-selectin), 5 nM (ICAM-1)
体内研究(In Vivo)	ICAM-1-IN-1 shows significant efficacy in a rat rheumatoid arthritis model and in a mouse asthma model. ICAM-1-IN-1 reduces the width of inflamed ankles after the ninth day following treatment, but shows no efficacy in the acute phase. Treatment with ICAM-1-IN-1 (25 mg/kg) for 21 days significantly reduces the ankle inflammation of the arthritis rats. Significant reduction of eosinophils and serum-soluble ICAM-1 (sICAM-1) is observed. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.

溶解度数据	In Vitro: DMSO : ≥ 135 mg/mL (371.67 mM)配制储备液

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[1]. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

ICAM-1-IN-1

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