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GRGDSP

目录号: PL14844 纯度: ≥99%

GRGDSP 是一种合成的线性RGD肽，是一种整联蛋白 (integrin) 抑制剂。

CAS No. :91037-75-1

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中文名称	GRGDSP
英文名称	GRGDSP
英文别名	L-Proline,glycyl-L-arginylglycyl-L-a-aspartyl-L-seryl-;glycyl-arginyl-glycyl-aspartyl-seryl-proline;GRGDSP;H-GLY-ARG-GLY-ASP-SER-PRO-OH;L-Proline, 1-[N-[N-[N-(N2-glycyl-L-arginyl)glycyl]-L-α-aspartyl]-L-seryl]- (ZCI);Glycyl-L-arginylglycyl-L-α-aspartyl-L-seryl-L-proline (ACI);103: PN: US20090257952 SEQID: 105 unclaimed protein;108: PN: WO2012045822 PAGE: 9 unclaimed sequence;10: PN: KR20170136178 PAGE: 3 claimed sequence;10: PN: KR20210147311 PAGE: 3 claimed sequence;10: PN: WO2012124998 SEQID: 10 unclaimed protein;11: PN: EP2463301 SEQID: 1 claimed sequence;11: PN: WO2004087736 SEQID: 11 unclaimed sequence;11: PN: WO2010125722 SEQID: 2 unclaimed protein;126: PN: WO2008058016 SEQID: 127 claimed protein;12: PN: JP2003089648 SEQID: 13 unclaimed;12: PN: US20140004158 SEQID: 13 claimed sequence;12: PN: US6713606 SEQID: 13 unclaimed sequence;12: PN: WO0182944 SEQID: 2 unclaimed sequence;12: PN: WO2014123399 SEQID: 34 claimed protein;134: PN: US20120121709 SEQID: 133 unclaimed sequence;13: PN: WO2020198685 SEQID: 44 claimed protein;14: PN: JP2004000070 SEQID: 16 unclaimed protein;14: PN: US20130052712 SEQID: 15 claimed protein;14: PN: WO03076596 SEQID: 14 unclaimed sequence;15: PN: KR20090132815 PAGE: 3 claimed sequence;15: PN: KR20090132911 SEQID: 110 claimed protein;15: PN: KR20160113372 SEQID: 15 claimed sequence;15: PN: KR20160129982 SEQID: 15 claimed sequence;15: PN: US6710030 SEQID: 15 unclaimed sequence;15: PN: WO2011025158 SEQID: 15 claimed sequence;15: PN: WO2023147053 SEQID: 59 claimed protein;16: PN: EP2455104 SEQID: 18 claimed protein;16: PN: JP2003210166 SEQID: 16 unclaimed protein;16: PN: JP2004049921 SEQID: 16 unclaimed protein;16: PN: US20190070313 SEQID: 16 claimed sequence;16: PN: WO2012065751 SEQID: 18 claimed protein;16: PN: WO2019046937 SEQID: 16 claimed protein;17: PN: KR20120114072 SEQID: 15 unclaimed protein;17: PN: WO2017171001 SEQID: 22 claimed protein;17: PN: WO2021231383 SEQID: 17 claimed protein;188: PN: WO2023004368 SEQID: 301 claimed protein;18: PN: JP2006087396 SEQID: 1 unclaimed protein;18: PN: WO2016022851 SEQID: 72 claimed protein;18: PN: WO2023147042 SEQID: 89 claimed protein;199: PN: WO2017040335 SEQID: 212 claimed protein;19: PN: US20090191645 SEQID: 19 unclaimed sequence;19: PN: US20120003201 SEQID: 17 claimed sequence;19: PN: WO2006089678 SEQID: 19 unclaimed sequence;1: PN: CN102145194 SEQID: 1 claimed sequence;1: PN: JP2009100679 SEQID: 1 unclaimed protein;1: PN: US20030059865 PAGE: 6 claimed protein;1: PN: US20110008443 SEQID: 1 claimed protein;1: PN: WO0025583 PAGE: 17 unclaimed sequence
Cas No.	91037-75-1
分子式	C₂₂H₃₇N₉O₁₀
分子量	587.58
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
详情描述	GRGDSP 是一种合成的线性RGD肽，是一种整联蛋白 (integrin) 抑制剂。

产品详情	GRGDSP 是一种合成的线性RGD肽，是一种整联蛋白 (integrin) 抑制剂。
生物活性	GRGDSP, a synthetic linear RGD peptide, is an integrin inhibitor.
性状	Solid
IC50 & Target[1][2]	Integrin
体外研究(In Vitro)	It is demonstrated that transarterial infusion of GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro integrin-inhibitor which includes RGD-peptide). As a synthetic linear RGD peptide, GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis. GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research. GRGDSP can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	GRGDSP
Sequence	Gly-Arg-Gly-Asp-Ser-Pro
参考文献	[1]. Qian J, et al. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9. [2]. Patel S, et al. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33.

溶解度数据	In Vitro: H₂O : 100 mg/mL (170.19 mM; Need ultrasonic)配制储备液

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[1]. Qian J, et al. Transarterial administration of integrin inhibitor loaded nanoparticles combined with transarterial chemoembolization for treating hepatocellular carcinoma in a rat model. World J Gastroenterol. 2016 Jun 7;22(21):5042-9.
[2]. Patel S, et al. Regulation of endothelial cell function by GRGDSP peptide grafted on interpenetrating polymers. J Biomed Mater Res A. 2007 Nov;83(2):423-33.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

GRGDSP

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