A-286982|280749-17-9|-陌孚医药/Medlife

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A-286982

目录号: PL14843 纯度: ≥99%

CAS No. :280749-17-9

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中文名称	A-286982
中文别名	(2E)-1-(4-乙酰基-1-哌嗪基)-3-[4-[[2-(1-甲基乙基)苯基]硫基]-3-硝基苯基]-2-丙烯-1-酮;(E)-1-(4-乙酰基哌嗪-1-基)-3-(4-((2-异丙基苯基)硫基)-3-硝基苯基)丙-2-烯-1-酮
英文名称	A-286982
英文别名	A 286982;A-286982;(E)-1-(4-acetylpiperazin-1-yl)-3-[3-nitro-4-(2-propan-2-ylphenyl)sulfanylphenyl]prop-2-en-1-one;(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one
Cas No.	280749-17-9
分子式	C₂₄H₂₇N₃O₄S
分子量	453.55
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	A-286982 是一种有效的变构 LFA-1/ICAM-1 相互作用抑制剂，在 LFA-1/ICAM-1 结合和 LFA-1 介导的细胞粘附试验中，IC₅₀ 分别为 44 nM 和 35 nM。
生物活性	A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC 50 s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively.
性状	Solid
IC50 & Target[1][2]	IC50: 44 nM (LFA-1/ICAM-1 interaction in an LFA-1/ICAM-1 binding assay) and 35 nM (LFA-1/ICAM-1 interaction in LFA-1-mediated cellular adhesion assay)
体外研究(In Vitro)	A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. G Liu, et al. Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead. J Me [2]. Susan M Keating, et al. Competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. Protein Sci. 2006 Feb;15(2):290-303.

溶解度数据	In Vitro: DMSO : 50 mg/mL (110.24 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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