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LXW7 TFA

目录号: PL14833 纯度: ≥99%

LXW7 TFA 是一种含 Arg-Gly-Asp (RGD) 的环状肽，是一种整合素 αvβ3 抑制剂，对 αvβ3 整联蛋白具有很高的结合亲和力，IC50 为 0.68 μM。LXW7 TFA 可增强 VEGFR-2 磷酸化和 ERK1/2 活化。具有抗炎活性。

商品编号	规格	价格	会员价
PL14833-1mg	1mg	¥21698.00	请登录
PL14833-5mg	5mg	¥45003.00	请登录
PL14833-10mg	10mg	¥61076.00	请登录
PL14833-50mg	50mg	询价	询价
PL14833-100mg	100mg	询价	询价

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中文名称	LXW7 TFA
英文名称	LXW7 TFA
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
详情描述	LXW7 TFA 是一种含 Arg-Gly-Asp (RGD) 的环状肽，是一种整合素 αvβ3 抑制剂，对 αvβ3 整联蛋白具有很高的结合亲和力，IC50 为 0.68 μM。LXW7 TFA 可增强 VEGFR-2 磷酸化和 ERK1/2 活化。具有抗炎活性。

产品详情	LXW7 TFA 是一种含 Arg-Gly-Asp (RGD) 的环状肽，是一种整合素 αvβ3 抑制剂，对 αvβ3 整联蛋白具有很高的结合亲和力，IC₅₀ 为 0.68 μM。LXW7 TFA 可增强 VEGFR-2 磷酸化和 ERK1/2 活化。具有抗炎活性。
生物活性	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor. LXW7 has a high binding affinity to αvβ3 integrin with an IC 50 of 0.68 μM. LXW7 TFA increases phosphorylation of VEGFR-2 and activation of ERK1/2. Anti-inflammatory effect.
性状	Solid
IC50 & Target[1][2]	IC50: 0.68 μM (αvβ3 integrin)
体外研究(In Vitro)	LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery. LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	LXW7 (100 μg/kg; intravenous injection) significantly lowers infarct volumes and brain water content (BWC) LXW7-treated rats. The LXW7 treatment lowers the expression of pro-inflammatory cytokines. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	CGRGDDVC-NH2 (Disulfide bridge:Cys1-Cys8)
Sequence	Cys-Gly-Arg-Gly-Asp-Asp-Val-Cys-NH2 (Disulfide bridge:Cys1-Cys8)
Solvent&Solubility	In Vitro: H₂O Peptide Solubility and Storage Guidelines:1. Calculate the length of the peptide.2. Calculate the overall charge of the entire peptide according to the following table:
参考文献	[1]. Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23. [2]. Hao D, et al. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086.

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[1]. Xiao W, et al. The use of one-bead one-compound combinatorial library technology to discover high-affinity αvβ3 integrin and cancer targeting arginine-glycine-aspartic acid ligands with a built-in handle. Mol Cancer Ther. 2010 Oct;9(10):2714-23.
[2]. Hao D, et al. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086.

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LXW7 TFA

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