RP 70676|136609-26-2|-陌孚医药/Medlife

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RP 70676

目录号: PL14721 纯度: ≥99%

CAS No. :136609-26-2

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产品详情	RP 70676 是一种有效的 ACAT 抑制剂，能够抑制对大鼠和兔子中的 ACAT 活性，IC₅₀ 值分别为 25 和 44 nM。
生物活性	RP 70676 is a potent inhibitor of ACAT, with IC 50 of 25 and 44 nM for rat and rabbit ACAT.
性状	Solid
IC50 & Target[1][2]	IC50: 25 nM (Rat ACAT), 44 nM (Rabbit ACAT)
体外研究(In Vitro)	RP 70676 is a potent inhibitor of rabbit arterial ACAT (IC50 = 40 nM) and has been shown to be an effective inhibitor of ACAT derived from a number of tissues and species including man. The IC50 values range from 21 nM for hamster liver ACAT to 108 nM for enzyme from the intestine of cholesterol fed rabbits; in human hepatic tissues the mean IC50 is 44 nM. In whole cell P388D, murine macrophages the compound has an IC50 of 540 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	RP 70676 (10 mg/kg, p.o.) is well absorbed with plasma levels in NZW rabbits. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. M.J. Ashton, et al. RP 70676: A potent systematically available inhibitor of acyl-CoA:cholesterol O-acyl transferase (ACAT). Bioorganic & Medicinal Chemistry Letters Volume 2, Issue 5, 1992, Pages 375-380.

溶解度数据	In Vitro: DMSO : 125 mg/mL (300.06 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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