Metyrapone|54-36-4|(美替拉酮; Su-4885)-陌孚医药/Medlife

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Metyrapone (Synonyms: 美替拉酮; Su-4885)

目录号: PL14634 纯度: ≥99%

CAS No. :54-36-4

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中文名称	Metyrapone
中文别名	美替拉酮;甲吡酮;烟酰吡丙烷;甲双吡丙酮;麦道中白朗;美替拉西酮;2-甲基-1,2-二-3-吡啶-1-丙酮;2-甲基-1,2-二-3-吡啶基-1-丙酮;美替拉酮 USP标准品
英文名称	Metyrapone
英文别名	2-Methyl-1,2-di-3-pyridyl-1-propanone;2-Methyl-1,2-di(3-pyridyl)-1-propanone;metyrapone;1-methyl-1-(3-pyridyl)ethyl 3-pyridyl ketone;2-methyl-1,2-dipyridin-3-ylpropan-1-one;Su-4885;Chlorisondamine diiodide;Methapyrapone;Methopirapone;Methopyrapone;Methopyrinine;Methopyrone;Metopiron;Metopirone;Metopyrone;Metyrapon;Methbipyranone;Mepyrapone;Metroprione;Metirapona;Metapyron;Metyraponum;Metapirone;Su 4885;Metapyrone;1-Propanone, 2-methyl-1,2-di-3-pyridinyl-;Metyraponum [INN-Latin];Metirapona [INN-Spanish];2-Methyl-1,2-di-3-pyridinyl-1-propanone;2-Methyl-1,2-bis(3-pyridyl)-1-propanone;s5416;Metyrapone (JP15/USP/INN);Metyrapone, United States Pharmacopeia (USP) Reference Standard;NCGC00016242-01;BCP19099;SPBio_002947;HMS2097F10;CS-4879;Q821641;HY-B1232;NSC 25265;HSDB 2500;metyrapon-;EX-A1403;MLS001335881;1-Propanone, 2-methyl-1,2-di-3-pyridyl-;AKOS015919707;METYRAPONE [USP-RS];METYRAPONE [JAN];BPBio1_000824;NSC760076;NCGC00016242-02;DTXSID1023314;Metyrapone, >=98% (HPLC), solid;Metyrapone [USAN:INN:BAN:JAN];Tox21_110323_1;Prestwick0_000904;AB00513955;SR-01000765398-2;2-methyl-1,2-di(pyridin-3-yl)propan-1-one;Prestwick1_000904;BSPBio_000748;METYRAPONE [USP MONOGRAPH];D70339;SR-01000765398;2-Methyl-1,2-di(3-pyridinyl)-1-propanone #;GTPL5224;MYT;NCGC00016242-05;Metyrapone [USAN:BAN:INN:JAN];HMS3742E21;DB01011;METYRAPONE [ORANGE BOOK];CCG-213598;LS-123097;MLS001335882;HMS3259O05;FT-0603230;METYRAPONE [INN];Metyrapone Alliance Brand;SMR000059134;HMS2235E16;Pharmakon1600-01506014;2-Methyl-1,2-di-3-pyridyl-1-propanone, 96%;BIDD:PXR0082;NSC25265;Metyrapone [USAN:USP:INN:BAN:JAN];UNII-ZS9KD92H6V;Novartis Brand of Metyrapone;Prestwick2_000904;MLS001066377;CHEMBL934;2-methyl-1,2-dipyridin-3-yl-propan-1-one;Su-4885; Su 4885; Su4885;NCGC00161837-01;EINECS 200-206-2;Prestwick3_000904;Metyrapone Novartis Brand;HMS1570F10;1,2-Di-3-pyridyl-2-methyl-1-propanone;D0Q9JT;A830124;AMY832;NSC-25265;DTXCID803314;ZS9KD92H6V;1-Propanone, 1,2-di-3-pyridyl-2-methyl-;Metyrapone (JP17/USP/INN);HMS3371B16;HMS3869K13;BDBM50028166;EN300-18532278;METYRAPONE [USAN];METYRAPONE [VANDF];54-36-4;HMS2094I07;BRD-K46862739-001-03-6;EU-0009322;2-methyl-1,2-bis(3-pyridyl)propan-1-one;CHEBI:44241;HMS3714F10;METYRAPONE [MART.];NCGC00016242-03;2-methyl-1,2-bis(pyridin-3-yl)propan-1-one;C07205;NC00462;METYRAPONE [MI];D00410;SCHEMBL637432;NSC-760076;CAS-54-36-4;1-Propanone,2-di-3-pyridinyl-;AS-56195;Z2289798161;Tox21_110323;METOPIRONE (TN);AB00513955_07;METYRAPONE [WHO-DD];METYRAPONE [HSDB];1-Propanone,2-di-3-pyridyl-;Alliance Brand of Metyrapone;Metyrapone
Cas No.	54-36-4
分子式	C₁₄H₁₄N₂O
分子量	226.27
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Metyrapone (Su-4885) 是一种有效且具有口服活性的 11β-羟化酶 (11β-hydroxylase) 抑制剂，可抑制醛固酮 (aldosterone) 的产生，也是一种细胞自噬 (autophagy) 激活剂。Metyrapone 能抑制内源性肾上腺皮质激素的合成，也会影响行为和情绪。此外，Metyrapone 可通过下调 mTOR 通路增加自噬过程的效率，也能与恶臭假单胞菌 (Pseudomonas putida) 细胞色素 P-450 (CYP450) 相互作用。Metyrapone 可用于研究库兴氏综合征 (Cushing's syndrome) 和抑郁症。

生物活性

Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushings syndrome and depression.

性状

Solid

IC50 & Target[1][2]

11β-hydroxylase, Aldosterone, CYP450, Autophagy

体外研究(In Vitro)

Metyrapone (100?μM; 2 h) hyperactivates autophagy in HepG2, and delays the activation of apoptosis at severe endoplasmic reticulum (ER) stress. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Metyrapone (25 or 50 mg/kg; SC, single dosage) decreases the stress-induced increase in plasma corticosterone levels, significantly impairs acquisition performance at high dosage, and increases open arm activity at low dosage. has not independently confirmed the accuracy of these methods. They are for reference only. Anim

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Roozendaal B, et al. Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory. Psychoneuroendocrinology. 1996 Nov;21(8):681-93.
[2]. Jahn H, et al. Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. Arch Gen Psychiatry. 2004 Dec;61(12):1235-44.

溶解度数据	In Vitro: DMSO : 100 mg/mL (441.95 mM; Need ultrasonic)H₂O : ≥ 38 mg/mL (167.94 mM)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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