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Anidulafungin (Synonyms: 阿尼芬净; LY303366)

目录号: PL14630 纯度: ≥99%

Anidulafungin 是一种新型的半合成棘球白素，具有抗真菌 (antifungal) 效力。

CAS No. :166663-25-8

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中文名称	Anidulafungin
中文别名	阿尼芬净;阿尼芬净-D11;阿尼分净;安多拉芬净;ANIDULAFUNGIN阿尼芬净;阿尼芬净杂质
英文名称	Anidulafungin
英文别名	Anidulafungin;C58H73N7O17;LY303366;Ecalta;Eraxis;V-Echinocandin;VER-002;1-[(4R,5R)-4,5-Dihydroxy-N2-[[4′′-(pentyloxy)[1,1′:4′,1′′-terphenyl]-4-yl]carbonyl]-L-ornithine]echinocandin B;LY 303366, Eraxis;Anidulafungin(LY303366);Echinocandin B, 1-(4R,5R)-4,5-dihydroxy-N2-4-(pentyloxy)1,1:4,1-terphenyl-4-ylcarbonyl-L-ornithine-;1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1'',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-echinocandin B;LY 303366;Anidulafungina;Anidulafunginum;Anidulafungine;Anidulafungin (LY303366);9HLM53094I;(4R,5R)-4,5-Dihydroxy-N(sup 2)-((4'-(pentyloxy)-p-terphenyl-4-yl)carbonyl)-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline cyclic (6-1)-peptide;Anidulafungin [USAN:INN];Anidulafungin [USAN:INN:BAN];Anidulafungin [USAN:INN
Cas No.	166663-25-8
分子式	C₅₈H₇₃N₇O₁₇
分子量	1140.20
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Anidulafungin 是一种新型的半合成棘球白素，具有抗真菌 (antifungal) 效力。

生物活性

Anidulafungin is a new semisynthetic echinocandin with antifungal potency.

性状

Solid

IC50 & Target[1][2]

Antifungal

体外研究(In Vitro)

Anidulafungin (LY-303366) has MICs of ≤0.32 μg/mL for all Candida albicans (n=99), Candida glabrata (n=18), and Candida tropicalis (n=10) isolates tested. Anidulafungin is also active against Aspergillus species (minimum effective concentration at which 90% of the isolates are inhibited, 0.02 μg/mL) (n=20), is less active against Candida parapsilosis (MIC at which 90% of the isolates are inhibited [MIC90], 5.12 μg/mL) (n=10), and is inactive against C. neoformans (MIC90 >10.24 μg/mL) (n=15) and B. dermatitidis (MIC90, 16 μg/mL) (n=29).The MICs of Fluconazole for three strains of C. tropicalis , seven strains of C. glabrata , and two strains of Candida krusei are ≥16 μg/mL. The MICs of Anidulafungin for 11 of these 12 strains range from 0.08 to 0.32 mg/mL. The twelfth strain is a C. krusei strain (Fluconazole MIC,

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Zhanel GG, et al. In vitro activity of a new semisynthetic echinocandin, LY-303366, against systemic isolates of Candida species, Cryptococcus neoformans, Blastomyces dermatitidis, and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5
[2]. Locke JB, et al. Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6100-7.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (87.70 mM)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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