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Micafungin sodium

(Synonyms: 米卡芬净钠; FK 463 sodium)

目录号: PL14631 纯度: ≥98.0%

Micafungin sodium (FK 463 sodium) 是抗真菌剂，抑制1, 3-beta-D-glucan的合成。

CAS No. :208538-73-2

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PL14631-200mg	200mg	询价	询价
PL14631-1 mL x 10 mM (in DMSO)	1 mL x 10 mM (in DMSO)	¥1455.00	请登录

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中文名称	Micafungin sodium
中文别名	米卡芬净钠;米卡芬净;米卡芬钠盐
英文名称	Micafungin sodium
英文别名	Micafungin Sodium;FK 463;Pneumocandin A0, 1-[(4R,5R)-4,5-dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threo;Caspofungin Acetate;L743873;MK0991;1-[(4R,5R)-4,5-Dihydroxy-N2-[4-[5-[4-(pentyloxy)phenyl]-3-isoxazolyl]benzoyl]-L-ornithine]-4-[(4S)-4-hydroxy-4-[4-hydroxy-3-(sulfooxy)phenyl]-L-threonine]pneumocandin A0 sodium salt;Mycamine;Sodium;[5-[(1R,2R)-2-[(3R,6R,9R,11S,15R,18R,20S,21S,24R,25R,26R)-3-[(1S)-3-amino-1-hydroxy-3-oxoprop;Micafungin sodium
Cas No.	208538-73-2
分子式	C₅₆H₇₀N₉NaO₂₃S
分子量	1292.26
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	Micafungin sodium (FK 463 sodium) 是抗真菌剂，抑制1, 3-beta-D-glucan的合成。

产品详情

Micafungin sodium (FK 463 sodium) 是抗真菌剂，抑制1, 3-beta-D-glucan的合成。

生物活性

Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.

性状

Solid

体外研究(In Vitro)

Micafungin (10 mg/mL) phenotypicly decreases the formation of biofilm in most of the isolates. For all the genes tested, the levels of mRNA transcription are also decreased significantly in micafungin-treated samples cf. their untreated counterparts. The combination of micafungin and KB425796-C is fungicidal and markedly reduces the number of CFU, in contrast to the fungistatic effects (no reduction in CFU) observed at all examined time points when each drug is used alone. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Micafungin (1 mg/kg) significantly prolongs survival compared with mice administered saline. Animals given a combination of micafungin (0.1 mg/kg) and KB425796-C (32 mg/kg) show a trend towards prolonged survival in comparison with those treated with micafungin (0.1 mg/kg) alone. In the livers of micafungin-treated mice, the number of CFUs decreases, although the clearance effect is less than that found in the kidneys. Combination treatment with micafungin and KB425796-C results in a significant decrease in the number of CFUs compared with the treatment with micafungin alone at all examined doses. The clearance effect associated with KB425796-C in combination with micafungin is greater than that observed in AMPH-treated animals. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Bazzi W, et al. The inhibitory effect of micafungin on biofilm formation by Pseudomonas aeruginosa. Biofouling. 2013 Jul 23.
[2]. Kai H, et al. Synergistic antifungal activity of KB425796-C in combination with micafungin against Aspergillus fumigat us and its efficacy in murine infection models. J Antibiot (Tokyo). 2013 Jun 12.

溶解度数据	In Vitro: H₂O : 100 mg/mL (77.38 mM; Need ultrasonic)DMSO : ≥ 32 mg/mL (24.76 mM)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Micafungin sodium

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