您当前的位置：

Seviteronel

(Synonyms: VT-464)

目录号: PL14553 纯度: ≥99%

Seviteronel (VT-464) 是 CYP17 裂解酶抑制剂，对h-Lyase的 IC50 为 69 nM。

CAS No. :1610537-15-9

商品编号	规格	价格	会员价
PL14553-2mg	2mg	¥3749.00	请登录
PL14553-5mg	5mg	¥2875.00	请登录
PL14553-10mg	10mg	¥4125.00	请登录
PL14553-50mg	50mg	¥8745.00	请登录
PL14553-100mg	100mg	¥11795.00	请登录
PL14553-200mg	200mg	询价	询价
PL14553-500mg	500mg	询价	询价
PL14553-10mM*1mLinDMSO	10mM*1mLinDMSO	¥4942.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	Seviteronel
中文别名	VT-464
英文名称	Seviteronel
英文别名	VT-464;Seviteronel;VT464;8S5OIN36X4;(S)-1-(6,7-bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-5-yl)propan-1-ol;1H-1,2,3-Triazole-5-methanol, alpha-(6,7-bis(difluoromethoxy)-2-naphthalenyl)-alpha-(1-methylethyl)-, (alphaS)-;1H-1,2,3-Triazole-5-methanol, alpha-[6,7-bis(difluoromethoxy)-2-naphthalenyl]-alpha-(1-methylethyl)-, (alphaS)-;Seviteronel;VT464;VT 464;DB12275;SB17087;Q21098941
Cas No.	1610537-15-9
分子式	C₁₈H₁₇F₄N₃O₃
分子量	399.34
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Seviteronel (VT-464) 是 CYP17 裂解酶抑制剂，对h-Lyase的 IC50 为 69 nM。

产品详情

Seviteronel (VT-464) 是 CYP17 裂解酶抑制剂，对h-Lyase的 IC₅₀ 为 69 nM。

生物活性

Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC 50 =69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition.

性状

Solid

IC50 & Target[1][2]

IC50: 69 nM(h-CYP17 Lyase).

体外研究(In Vitro)

Seviteronel (VT-464), a non-steroidal small molecule inhibits androgen production without mineralocorticoid excess or cortisol depletion by selective inhibition of CYP17 17,20-lyase. We determined the impact of Seviteronel (VT-464) on tumor growth of a mCRPC xenograft, MDA-PCa-133, in vivo, and on androgen signaling in C4-2B prostate cancer cells in vitro. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

The MDA-PCa-133 xenograft is derived from a clinical CRPC bone metastasis. Subcutaneous MDA-PCa-133 tumor expresses PSA, full-length androgen receptor (AR) and AR-V7 isoform. We determined the effect of Seviteronel (VT-464) and AA on MDA-PCa-133 growing in tumor-bearing castrated male mice: randomization into three groups; oral treatment with vehicle only, VT-464, (100 mg/kg bid), or AA (100 mg/kg bid) for 25 days. Both Seviteronel (VT-464) and AA reduced tumor volume (>two fold compared to vehicle; p<0.05). These results indicate that selective Seviteronel (VT-464) CYP17 lyase inhibition is as effective as AA CYP17 inhibition in this model [2]. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors. Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7.
[2]. Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models. Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (125.21 mM)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Seviteronel

相关产品

The molarity calculator equation

The dilution calculator equation