Pyributicarb|88678-67-5|(TSH-888)-陌孚医药/Medlife

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Pyributicarb (Synonyms: TSH-888)

目录号: PL14545 纯度: ≥99%

Pyributicarb 是一种氨基甲酸酯型除草剂，是 CYP3A4 基因和人类孕烷 X 受体 (hPXR) 的有效激活剂。

CAS No. :88678-67-5

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中文名称	Pyributicarb
中文别名	稗草畏;O-3-特丁基苯基-6-甲氧基-2-吡啶(甲基)硫代氨基甲酸酯;椑草畏;O-3-特丁基苯基-6-甲氧基-2-(吡啶(甲基)硫代氨基甲酸酯;O-3-特丁基苯基-6-甲氧基-2-吡啶(甲基)硫代氨基甲酸酯(稗草畏);稗草丹;稗草丹(稗草畏);WAKO160-25111稗草畏标准品;稗草丹标准品;稗草畏标准品;稗草畏标准物质;芬罗贝特;稗草畏,O-3-特丁基苯基-6-甲氧基-2-(吡啶(甲基)硫代氨基甲酸酯
英文名称	Pyributicarb
英文别名	Pyributicarb;carbamothioicacid,(6-methoxy-2-pyridinyl)methyl-,o-(3-(1,1-dimethylethyl)p;n-(6-methoxy-2-pyridyl)-n-methyl-thiocarbamicacio-3-tert-butylphenyleste;tsh-888;PYRIBUTYCARB;n-(6-methoxy-2-pyridyl)-n-methylthiocarbamic acid o-3-tert-butylphenyl ester;O-3-tert-Butylphenyl (6-methoxy-2-pyridyl)(methyl)thiocarbamate;O-(3-tert-butylphenyl) N-(6-methoxypyridin-2-yl)-N-methylcarbamothioate;Carbamothioic acid,(6-methoxy-2-pyridinyl)methyl-,O-;O-(3-tert-butylphenyl) (6-methoxypyridin-2-yl)methylcarbamothioate;O-[3-(1,1-dimethylethyl)phenyl] N-(6-methoxy-2-pyridinyl)-N-methylcarbamothioate;O-3-tert-butylphenyl 6-methoxy-2-pyridyl(methyl)thiocarbamate;Pyributicarb [ISO];Thiocarbamic acid,N-(6-methoxy-2-pyridyl)-N-methyl-,O-3-tert-butylphenyl ester;Carbamothioic acid, (6-methoxy-2-pyridinyl)methyl-, O-[3-(1,1-dimethylethyl)phenyl] ester (9CI);Isshintasuke;Isshintasuke flowable;O-3-tert-Butylphenyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate;TSH 888
Cas No.	88678-67-5
分子式	C₁₈H₂₂N₂O₂S
分子量	330.44
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Pyributicarb 是一种氨基甲酸酯型除草剂，是 CYP3A4 基因和人类孕烷 X 受体 (hPXR) 的有效激活剂。
生物活性	Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).
性状	Solid
IC50 & Target[1][2]	CYP3A4, hPXR
体外研究(In Vitro)	Pyributicarb, a carbamate-type herbicide, is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR). Pyributicarb is found to increase the CYP3A4 reporter activity at 0.1 to 1 μM more strongly than typical CYP3A4 inducer rifampicin. Expression of hPXR-siRNA clearly diminishes the Pyributicarb-stimulated CYP3A4 reporter activity in 3-1-10 cells and decreases the endogenous CYP3A4 mRNA levels in HepG2 cells. Pyributicarb induces luciferase transcription via hPXR at low concentrations in the order of 10 nM. The relative potency of Pyributicarb for hPXR is 8.6-fold that of rifampicin (RIF). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Pyributicarb causes enhancement of CYP3A4-derived reporter activity in mouse livers introduced with hPXR by adenovirus. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Matsubara T, et al. Assessment of human pregnane X receptor involvement in pesticide-mediated activation of CYP3A4 gene. Drug Metab Dispos. 2007 May;35(5):728-33. [2]. Kojima H, et al. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb 27;280(3):77-87.

溶解度数据	In Vitro: DMSO : 100 mg/mL (302.63 mM; Need ultrasonic)配制储备液

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