Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC 50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.
Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β.Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
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储存方式
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ClinicalTrial
参考文献
[1]. Dhimolea E. Canakinumab. MAbs. Epub 2010 Jan 15. [2]. Rondeau JM, et al. The molecular mode of action and species specificity of canakinumab, a human monoclonal antibody neutralizing IL-1β. MAbs. 2015;7(6):1151-60.