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RP-54745

目录号: PL13354 纯度: ≥99%

RP-54745 是一种潜在的治风湿化合物，能够抑制噬细胞刺激和的白介素-1 (interleukin-1) 的产生。

CAS No. :135330-08-4

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PL13354-1mg	1mg	¥537.00	请登录
PL13354-5mg	5mg	¥1315.00	请登录
PL13354-10mg	10mg	¥2115.00	请登录
PL13354-20mg	20mg	¥9643.00	请登录
PL13354-50mg	50mg	¥5425.00	请登录
PL13354-100mg	100mg	¥7625.00	请登录
PL13354-10mM*1mLinDMSO	10mM*1mLinDMSO	¥5265.00	请登录
PL13354-1 mL x 10 mM (in DMSO)		¥1185.00	请登录

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中文名称	RP-54745
英文名称	RP-54745
英文别名	4-chloro-5-(1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-3H-1,2-dithiol-3-one;3H-1,2-Dithiol-3-one, 4-chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-;4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one;4-chloro-5-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)dithiol-3-one;RP54745;RP-54745
Cas No.	135330-08-4
分子式	C₁₃H₁₂NOs₂Cl
分子量	297.82
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	RP-54745 是一种潜在的治风湿化合物，能够抑制噬细胞刺激和的白介素-1 (interleukin-1) 的产生。

产品详情	RP-54745 是一种潜在的治风湿化合物，能够抑制噬细胞刺激和的白介素-1 (interleukin-1) 的产生。
生物活性	RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
性状	Solid
IC50 & Target[1][2]	IL-1
体外研究(In Vitro)	RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. [2]. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (209.86 mM; Need ultrasonic)配制储备液

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[1]. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26.
[2]. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

RP-54745

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