Terlipressin acetate|1884420-36-3|(醋酸特利加压素)-陌孚医药/Medlife

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Terlipressin acetate (Synonyms: 醋酸特利加压素)

目录号: PL12523 纯度: ≥99%

CAS No. :1884420-36-3

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PL12523-100mg	100mg	¥4259.00	请登录
PL12523-200mg	200mg	询价	询价
PL12523-500mg	500mg	询价	询价

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中文名称	Terlipressin acetate
英文名称	Terlipressin acetate
英文别名	Terlipressin acetate
Cas No.	1884420-36-3
包装储存	Stored under nitrogen, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情

Terlipressin acetate 是一种具有血管活性的加压素类似物，也是一种高度选择性的加压素 V1 受体激动剂，可减少内脏血流量和门脉压力并控制急性静脉曲张破裂出血。Terlipressin acetate 具有抗炎和抗氧化作用，可用于肝肾综合征和耐去甲肾上腺素的败血性休克的研究。

生物活性

Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.

性状

Solid

IC50 & Target[1][2]

Vasopressin V1 receptor

体外研究(In Vitro)

Terlipressin (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells.
Terlipressin inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Using a mouse nonlethal hepatic ischemia-reperfusion (IR) model, Terlipressin administration significantly ameliorates IR-induced liver apoptosis, necrosis and inflammation. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Stored under nitrogen, away from moisturePowder -80°C 2 years；-20°C 1 year

ClinicalTrial

SequenceShortening

GGGCYFQNCPKG-NH2 (Disulfide bridge: Cys4-Cys9)

Sequence

Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys4-Cys9)

参考文献

[1]. Zi-Meng Liu, et al. Terlipressin Protects Intestinal Epithelial Cells Against Oxygen-Glucose Deprivation/Re-Oxygenation Injury via the Phosphatidylinositol 3-kinase Pathway. Exp Ther Med. 2017 Jul;14(1):260-266.
[2]. Yeun Tarl Fresner Ng Jao, et al. Refractory Torsade De Pointes Induced by Terlipressin (Glypressin). Int J Cardiol. 2016 Nov 1;222:135-140.

溶解度数据	In Vitro: H₂O : 100 mg/mL (74.21 mM; Need ultrasonic)DMSO : 50 mg/mL (37.11 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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