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XRK3F2

目录号: PL13112 纯度: ≥98%

XRK3F2 是 p62 (Sequestosome-1)-ZZ 结构域的抑制剂。

CAS No. :2375193-43-2

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中文名称	XRK3F2
英文名称	XRK3F2
英文别名	XRK3F2;2-((3,4-Bis((4-fluorobenzyl)oxy)benzyl)amino)ethanol hydrochloride;2-[[3,4-bis[(4-fluorophenyl)methoxy]phenyl]methylamino]ethanol;hydrochloride;s8756;D80186
Cas No.	2375193-43-2
分子式	C₂₃H₂₄ClF₂NO₃
分子量	435.89
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	XRK3F2 是 p62 (Sequestosome-1)-ZZ 结构域的抑制剂。

产品详情	XRK3F2 是 p62 (Sequestosome-1)-ZZ 结构域的抑制剂。
生物活性	XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain.
性状	Solid
IC50 & Target[1][2]	P62-ZZ domain.
体外研究(In Vitro)	The presence of XRK3F2 during MM-preOB co-cultures prevents Runx2 suppression at both d0 and d4. Furthermore, XRK3F2 blocks MM-induced upregulation of Gfi1 . XRK3F2 blocks the induction of Gfi1 mRNA in BMSC in both treatment conditions. In contrast, XRK3F2 prevents both MM1.S CM and TNFα plus IL7-mediated Runx2 suppression. Further, the pro-inflammatory and myeloma pro-survival factor IL6 mRNA is also reduced by XRK3F2 treatment. In addition, XRK3F2 also prevents TNFα-mediated upregulation of Gfi1 and rescues inhibition of Runx2 in MC4 preOB. XRK3F2 prevents MM-induced GFI1 occupancy at the Runx2 -P1 promoter. XRK3F2 treatment significantly rescues the H3K9ac levels at Runx2 in MM patient hBMSC and XRK3F2 can rescue early steps in osteogenesis. has not independently confirmed the
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.

溶解度数据	In Vitro: DMSO : 150 mg/mL (344.12 mM; Need ultrasonic)H₂O : 0.91 mg/mL (2.09 mM; Need ultrasonic)配制储备液

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[1]. Adamik J, et al. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

XRK3F2

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