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ST034307

目录号: PL09231

ST034307 是一种有效的，选择性的 adenylyl cyclase 1 抑制剂，IC50 值为 2.3 μM。

CAS No. :133406-29-8

中文名称	ST034307
中文别名	6-氯-2-(三氯甲基)-4H-苯并吡喃-4-酮;化合物ST034307
英文名称	ST034307
英文别名	6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one;6-Chloro-2-(trichloromethyl)chromen-4-one;ST034307;6-chloro-2-(trichloromethyl)-4H-chromen-4-one;ST-034307;ST 034307;4H-1-Benzopyran-4-one, 6-chloro-2-(trichloromethyl)-;ST034307 >=98% (HPLC)
Cas No.	133406-29-8
分子式	C₁₀H₄Cl₄O₂
分子量	297.95
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	ST034307 是一种有效的，选择性的 adenylyl cyclase 1 抑制剂，IC50 值为 2.3 μM。

产品详情	ST034307 是一种有效的，选择性的 adenylyl cyclase 1 抑制剂，IC₅₀ 值为 2.3 μM。
生物活性	ST034307 is a potent and selective adenylyl cyclase 1 (AC1) inhibitor, with IC 50 of 2.3 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 2.3 μM (AC1)
体外研究(In Vitro)	ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 significantly inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. In contrast, ST034307 has no significant effects in the wild-type HEK cells. ST034307 significantly inhibits the Ca/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of MOR-mediated sensitization of AC1. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ST034307 (0.25 μg) causes a significant relief of CFA-induced inflammatory pain in mice. ST034307 exhibits an estimated median effective dose (E 50 ) value for analgesia of 0.28 μg in the mouse pain model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Brust TF, et al. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci Signal. 2017 Feb 21;10(467).

溶解度数据	In Vitro: DMSO : 16.67 mg/mL (55.95 mM; Need ultrasonic)配制储备液

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[1]. Brust TF, et al. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci Signal. 2017 Feb 21;10(467).

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

ST034307

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