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Fabomotizole hydrochloride

(Synonyms: CM346 hydrochloride)

目录号: PL09410 纯度: ≥99%

Fabomotizole hydrochloride (CM346 hydrochloride)是一种具有抗焦虑和神经保护活性的化合物。

CAS No. :173352-39-1

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中文名称	Fabomotizole hydrochloride
中文别名	Fabomotizole (hydrochloride)
英文名称	Fabomotizole hydrochloride
英文别名	1H-Benzimidazole, 5-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-,monohydrochloride;4-[2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]ethyl]morpholine,hydrochloride;CM346 hydrochloride;CM-346 hydrochloride;Afobazole (hydrochloride);Fabomotizole (hydrochloride);Afobazole hydrochloride, >=98%;Afobazole hydrochloride;Fabomotizole hydrochloride;Afobazol HCl;HDO6HX6NZU;Aphobazole;Afobazol;4-(2-((5-ethoxy-1H-benzo[d]imidazol-2-yl)thio)ethyl)morpholine hydrochloride;Fabomotizole?hydrochloride;CM 346 HCl;BCP29097;S2474;2-((2-Morpholino)ethylthio)-5-ethoxybenzimidazole;Q27279879;2-[2-(morpholino)-ethylthio]-5-ethoxy-benzimidazole hydrochloride;5-e
Cas No.	173352-39-1
分子式	C₁₅H₂₂ClN₃O₂S
分子量	343.87
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Fabomotizole hydrochloride (CM346 hydrochloride)是一种具有抗焦虑和神经保护活性的化合物。

产品详情	Fabomotizole hydrochloride (CM346 hydrochloride)是一种具有抗焦虑和神经保护活性的化合物。
生物活性	Fabomotizole hydrochloride (CM346 hydrochloride) is an anxiolytic drug. Fabomotizole hydrochloride produces anxiolytic and neuroprotective effects without any muscle relaxant actions.
性状	Solid
体外研究(In Vitro)	Afobazoles mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Afobazole, From Wikipedia

溶解度数据	In Vitro: H₂O : 100 mg/mL (290.81 mM; Need ultrasonic)DMSO : ≥ 44 mg/mL (127.96 mM)

搜索质检报告(COA)

[1]. Afobazole, From Wikipedia

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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