HQ-415|430462-93-4|-陌孚医药/Medlife

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HQ-415

目录号: PL09409 纯度: ≥98%

HQ-415是一种与Clioquinol相关的具有生物活性的金属螯合剂, EC50为15 μM。

CAS No. :430462-93-4

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中文名称	HQ-415
中文别名	HQ-415
英文名称	HQ-415
英文别名	HQ-415;7-[(3-ethoxy-4-methoxyphenyl)-[(4-methylpyridin-2-yl)amino]methyl]quinolin-8-ol;7-{(3-ethoxy-4-methoxyphenyl)[(4-methylpyridin-2-yl)amino]methyl}quinolin-8-ol;HMS1803A09;STK509332
Cas No.	430462-93-4
分子式	C₂₅H₂₅N₃O₃
分子量	415.48
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	HQ-415是一种与Clioquinol相关的具有生物活性的金属螯合剂, EC50为15 μM。
生物活性	HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ-415 is 15 μM. IC50 value: 15 μM (EC50) in vitro: In TDP-43-expressing cells, CQ fails to synergize with HQ-161 and actually antagonizes HQ-161 rescuing activity. In contrast, despite the fact that CQ was completely inactive against TDP-43, it strongly synergized with HQ-415, decreasing the EC50 from 16 to 5 μM. HQ-415 is active in the TDP-43 model, but CQ was not HQ-161 and HQ-415 are retested in dose for their ability to rescue TDP-43. Both HQ-161 and HQ-415 rescue TDP-43 toxicity. In cells expressing α-syn, HQ-161, despite being inactive on its own, synergized with HQ-415, reducing the EC50 from 21 to 14 μM. HQ-415 strongly synergizes with CQ at multiple concentrations in cells expressing α-syn.
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Tardiff DF, et al. Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem. 2012 Feb 3;287(6):4107-4120.

溶解度数据	In Vitro: DMSO : 5.6 mg/mL (13.48 mM; Need ultrasonic and warming)配制储备液

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