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Thimerosal

目录号: PL09209 纯度: ≥98.0%

Thimerosal 是一种含汞疫苗防腐剂，也是神经发育障碍病因中的一个可疑因素。

CAS No. :54-64-8

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中文名称	Thimerosal
中文别名	硫柳汞;硫柳汞钠;乙汞硫水杨酸钠盐;乙汞硫柳酸鈉;Mercury-([o-carboxyphenyl]thio)ethyl 钠盐;乙基噻吩酸钠盐;乙汞硫柳酸钠;乙汞硫水杨酸钠盐;凝结,餐具配套,装窑,残余变形,套,组台,设定;乙基噻吩酸钠盐;硫柳汞酸钠;乙基噻吩酸钠盐/硫柳汞钠/硫柳汞
英文名称	Thimerosal
英文别名	Thimerosal;Thiomersal;Merthiolate sodium;THIOMERSAL, PHARMACEUTICAL GRADE;ETHYLMERCURITHIOSALICYLIC ACID NA;Mercurothiolate;MERTHIOLATE;sodium 2-(ethylmercuriothio)benzoate;sodium ethyl[2-(mercapto-κS)benzoato(2?)-κO]mercurate(1?);Sodium ethylmercurithiosalicylate;Sodium merthiolate;sodium salt of (2-carboxyphenylthio)ethylmercury;sodium,(2-carboxylatophenyl)sulfanyl-ethylmercury;Thimerosalate;Thimerosalum;Thimersalate;Thiomersalate;([o-Carboxyphenyl]thio)ethylmercury sodium salt;2-(Ethylmercuriomercapto)benzoic acid sodium salt;Ethylmercurithiosalicylic acid sodium salt;2-(Ethylmercurio(II)thio)benzoic acid sodium;2-(Ethylmercurio(II)thio)benzoic acid sodium salt;Thimerosal ,98%;Ethylmercury thiosalicylic acid sodium salt;Ethylmercurithiosalicylic Acid Sodium Salt Sodium Ethylmercurithiosalicylate;Thimerosal ,97% [sodium salt, 97.0-101.0%];ETHYLMERCURY THIOSALICYLICACID.NA-SALT RESEARCH GRADE;Thimerosal,2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate
Cas No.	54-64-8
分子式	C₉H₉HgNaO₂S
分子量	404.81
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Thimerosal 是一种含汞疫苗防腐剂，也是神经发育障碍病因中的一个可疑因素。

产品详情	Thimerosal 是一种含汞疫苗防腐剂，也是神经发育障碍病因中的一个可疑因素。
生物活性	Thimerosal, a mercury-containing vaccine preservative, is a suspected factor in the etiology of neurodevelopmental disorders.
性状	Solid
体内研究(In Vivo)	The Thimerosal (THIM) administration increases μ-opioid receptors (MORs) density in the periaqueductal gray (PAG) in a dose-dependent manner. Treatment with higher doses of Thimerosal statistically significantly increases MOR density in the dorsomedial periaqueductal gray (DMPAG) and lateral periaqueductal gray (LPAG) regions. At the dose 3,000 μg Hg/kg, Thimerosal also augments MOR density in the caudate putamen (CPU). In contrast, the administration of Thimerosal at both higher doses decreases MOR density in the dentate gyrus (DG). Thimerosal administration (4 injections, i.m., 240 μg Hg/kg on postnatal days 7, 9, 11, 15) induces lasting changes in amino acid overflow: an increase of glutamate and aspartate accompanied by a decrease of glycine and alanine; measured 10 to 14 weeks after the injections. Four injections of Thimerosal at a dose of 12.5 μg Hg/kg do not alter glu
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Olczak M, et al. Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the ratbrain. Neurochem Res. 2010 Nov;35(11):1840-7. [2]. Duszczyk-Budhathoki M, et al. Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate. Neurochem Res. 2012 Feb;37(2):436-47.

溶解度数据	In Vitro: H₂O : 100 mg/mL (229.95 mM; Need ultrasonic and warming)配制储备液

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[1]. Olczak M, et al. Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the ratbrain. Neurochem Res. 2010 Nov;35(11):1840-7.
[2]. Duszczyk-Budhathoki M, et al. Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate. Neurochem Res. 2012 Feb;37(2):436-47.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Thimerosal

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