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D-JBD19

目录号: PL09150 纯度: ≥99%

D-JBD19 是一种不可渗透性的多肽。D-JBD19 具有神经保护作用。

CAS No. :954134-42-0

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中文名称	D-JBD19
英文名称	D-JBD19
英文别名	H-D-Asp-D-Gln-D-Ser-D-Arg-D-Pro-D-Val-D-Gln-D-Pro-D-Phe-D-Leu-D-Asn-D-Leu-D-Thr-D-Thr-D-Pro-D-Arg-D-Lys-D-Pro-D-Arg-OH;D-α-Aspartyl-D-glutaminyl-D-seryl-D-arginyl-D-prolyl-D-valyl-D-glutaminyl-D-prolyl-D-phenylalanyl-D-leucyl-D-asparaginyl-D-leucyl-D-threonyl-D-threonyl-D-prolyl-D-arginyl-D-lysyl-D-prolyl-D-arginine (ACI);D;1: PN: WO2010072405 SEQID: 122 claimed sequence;2: PN: WO2009143864 SEQID: 2 claimed protein;2: PN: WO2009144037 SEQID: 2 claimed protein;2: PN: WO2013079213 SEQID: 2 claimed protein;2: PN: WO2014206427 SEQID: 2 claimed sequence;2: PN: WO2015197098 SEQID: 2 claimed sequence;D-JBD19
Cas No.	954134-42-0
分子式	C₉₉H₁₆₄N₃₂O₂₈
分子量	2250.56
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
详情描述	D-JBD19 是一种不可渗透性的多肽。D-JBD19 具有神经保护作用。

产品详情	D-JBD19 是一种不可渗透性的多肽。D-JBD19 具有神经保护作用。
生物活性	D-JBD19 is a non-permeable peptide. D-JBD19 has neuroprotective effects.
性状	Solid
体外研究(In Vitro)	D-JBD19 is a non-permeable cargo corresponding to dJNKi peptide. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Neuroprotective effects of D-JBD19 against middle cerebral artery occlusion (MCAO) as compared with D-JNKI1. 15.7 ng of either D-JBD19 or D-JNKI1 or 1570 ng of D-JBD19 are injected i.c.v. just after the ischemia. Animals were killed 24 h later. 100 times more D-JBD19 is needed to provide protection than with D-JNKI1. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	DQSRPVQPFLNLTTPRKPR
Sequence	Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg
参考文献	[1]. Cardozo AK, et al. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. [2]. Vaslin A, et al. Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor. J Neurochem. 2011 Dec;119(6):1243-52.

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[1]. Cardozo AK, et al. Cell-permeable peptides induce dose- and length-dependent cytotoxic effects. Biochim Biophys Acta. 2007 Sep;1768(9):2222-34.
[2]. Vaslin A, et al. Excitotoxicity-induced endocytosis mediates neuroprotection by TAT-peptide-linked JNK inhibitor. J Neurochem. 2011 Dec;119(6):1243-52.

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D-JBD19

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