Phensuximide|86-34-0|-陌孚医药/Medlife

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Phensuximide

目录号: PL09171 纯度: ≥99%

CAS No. :86-34-0

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中文名称	Phensuximide
中文别名	苯琥胺;米浪丁;密朗丁;苯琥胺 USP标准品
英文名称	Phensuximide
英文别名	phensuximide;Phensuximide [INN:BAN];( -)-N-Methyl-2-phenylsuccinimide;1-Methyl-3-phenyl-2,5-pyrrolidinedione;1-Methyl-3-phenylpyrrolidin-2,5-dione;PHENSUXIMIDE, USP STANDARD;1-Methyl-3-phenyl-pyrrolidin-2,5-dion;1-methyl-3-phenyl-pyrrolidine-2,5-dione;1-methyl-3-phenylsuccinimide;Epimal;Epimid;Lifen;Lifene;Milontin;Milonton;Mirontin;Mirotin;N-methylphenylsuccinimide;PM 334;Phensuximide
Cas No.	86-34-0
分子式	C₁₁H₁₁NO₂
分子量	189.21
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Phensuximide 是一种琥珀酰亚胺类抗癫痫 (antiepileptic) 和抗惊厥 (anticonvulsant) 试剂。Phensuximide 可以抑制去极化脑组织中 cyclic AMP 和 cyclic GMP 的积累。在动物模型中，Phensuximide 可用于癫痫研究的相关研究。
生物活性	Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal.
性状	Solid
IC50 & Target[1][2]	IC50: cyclic AMP and cyclic GMP accumulation
体外研究(In Vitro)	Phensuximide produce depolarization-induced accumulation of cyclic GMP or cyclic AMP levels with ID50 values of 8.00 mM or 6.20 mM in incubated slices of mouse cerebral cortex. Phensuximide (0.5-2.0 mM) has the ability to competitively inhibit mephenytoin 4-hydroxylase activity in human liver microsomes, the Ki and Km values are 559 μM and 235 μM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Phensuximide (intraperitoneal injection; 1.25 mmol/kg; single dose) induces mild changes in renal function, including: trace hematuria, increased proteinuria and decreased paminohippurate uptake in Sprague-Dawley rats. Phensuximide (intraperitoneal injection; 0.3 or 0.6 mmol/kg; 5-7 days) results in transient hematuria and proteinuria, but no change in the other renal function parameters studied. It is concluded that phensuximide produces mild, transient renal effects in Fischer 344 rats, and that the Fischer 344 rat is a suitable model for studying phensuximide-induced toxicity to the urinary tract. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. G O Rankin, et al. Urinary Tract Effects of Phensuximide in the Sprague-Dawley and Fischer 344 Rat. J Appl Toxicol. . 1986 Oct;6(5):349-56. [2]. J A Ferrendelli, et al. Inhibitory Effects of Anticonvulsant Drugs on Cyclic Nucleotide Accumulation in Brain. Ann Neurol. 1979 Jun;5(6):533-8. [3]. J G MILLICHAP

溶解度数据	In Vitro: DMSO : 250 mg/mL (1321.28 mM; Need ultrasonic)配制储备液

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