SKF-86002|72873-74-6|-陌孚医药/Medlife

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SKF-86002

目录号: PL08722 纯度: ≥99%

CAS No. :72873-74-6

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中文名称	SKF-86002
中文别名	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-b]-噻唑;SKF-86002 抑制剂
英文名称	SKF-86002
英文别名	6-(4-Fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole;6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-Imidazo[2,1-b]thiazole;6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole;Imidazo[2,1-b]thiazole,6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-;SKF-86002;6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole;6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole;6-(4-fluorophenyl)-5-pyridin-4-yl-2,3-dihydroimidazo[2,1-b][1,3]thiazole dihydrochloride;Imidazo(2,1-b)thiazole, 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-;SK&F 86002;SK&F 86002-A(2);Skf 86002;6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole;6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole;6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE;9R6QDF1UO7;5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo(2,1-b)-thiazole;4-[6-(4-fluorophenyl)-2H,3H-imidazo[2,1-b][1,3]thiazol-5-yl]pyridine;Imidazo[2,1-b]thiazole,6-(4-fluo
Cas No.	72873-74-6
分子式	C₁₆H₁₂FN₃S
分子量	297.35
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	SKF-86002 是一种具有口服活性的 p38 MAPK 抑制剂，具有抗炎、抗关节炎活性，可用于缓解疼痛的研究。SKF-86002 抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α (IC₅₀ = 1 μM)。SKF-86002 能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢。
生物活性	SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC 50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.
性状	Solid
体外研究(In Vitro)	SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Lewis rats, with adjuvant-induced arthritis (AA)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97. [2]. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (112.09 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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