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Thioacetamide

(Synonyms: Acetothioamide; TAA; Thiacetamide)

目录号: PL07700 纯度: ≥98.0%

Thioacetamide (TAA) 是一种间接的肝毒素，可引起实质细胞坏死。Thioacetamide 通过微粒体 CYP2E1 代谢激活最初为硫代乙酰胺-S-氧化物，然后再转化为硫代乙酰胺-S-二氧化物，这是一种高度活性的代谢物，其活性代谢物与蛋白质和脂质共价结合，从而引起氧化应激和小叶中央坏死。Thioacetamide 可诱发慢性肝纤维化、脑病等事件模型。

CAS No. :62-55-5

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中文名称	Thioacetamide
中文别名	硫代乙酰胺;乙硫酰胺;硫代酰胺;硫代乙醯胺;硫乙醯胺;乙硫羰醯胺;乙硫醯胺;硫代乙酰胺, ACS;Thioacetamide 硫代乙酰胺;硫代乙酰胺,AR;硫代乙酰胺医药中间体;硫乙酰胺;维生素H添加剂-硫代乙酰胺;优质高纯度，硫代乙酰胺
英文名称	Thioacetamide
英文别名	Thioacetamide;ETHANETHIOAMIDE;TAA;THIOACETAMIDE TS;Acetamide, thio-;Acetimidic acid, thio-;Acetothioamide;CH3CSNH2;Rcra waste number U218;Thiacetamide;thio-acetamid;thioacetimidicacid;Thioactamide;thiono-aceticaciamide;USAF cb-21;USAF ek-1719;hioacetamide;Thioacetimidic acid;Acetic acid, thiono-, amide;methylthioamide;Ethanimidothioic acid;acetic acid thioamide;RCRA waste no. U218;YUKQRDCYNOVPGJ-UHFFFAOYSA-N;075T165X8M;Thiacetamid;Thioacetamide, 99+%, ACS reagent;C2H5NS;thioacteamide;thio;MFCD00008070;NSC2120;Thioacetamide, ACS reagent;USAF EK-1719;D70870;THIOACETAMIDE [HSDB];YUKQRDCYNOVPGJ-UHFFFAOYSA-;NSC-2120;NSC 2120;C19302;Thioacetamide, p.a., ACS reagent, 99%;Q416253;DTXSID9021340;AKOS000119931;HSDB 1318;BP-10926;InChI=1/C2H5NS/c1-2(3)4/h1H3,(H2,3,4);CAS-62-55-5;CHEBI:32497;62-55-5;CCRIS 584;USAF CB-21;Thiocetamide solution;Ethanethioamide;Acetothioamide;AI3-17220;FT-0631278;bmse000781;EC 200-541-4;CHEMBL38737;STR00411;UNII-075T165X8M;Thioacetamide, ACS reagent, for the precipitation (of heavy metals), >=99.0%;RCRA waste number U218;Tox21_301295;Ethanethioamide;thioacetoamide;Etanotioamida;J-520440;Ethanethioamide; Acetothioamide; Thiacetamide;Thioacetamide, Vetec(TM) reagent grade, 98%;DTXCID901340;Z104474020;THIOACETAMIDE;THIOACETAMIDE [MI];Tioacetammide;C2-H5-N-S;Tioacetamida;A833844;EN300-19496;THIOACETAMIDE [IARC];STL199139;T0187;Acetamide, thio- (VAN);BCP30336;HY-Y0698;Thioacetamide, reagent grade, 98%;EINECS 200-541-4;F0001-1649;NCGC00257539-01;WLN: ZY1&US;CS-W018499;LS-1480;Thioacetamide, ACS reagent, >=99.0%
Cas No.	62-55-5
分子式	C₂H₅NS
分子量	75.13
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
详情描述	Thioacetamide (TAA) 是一种间接的肝毒素，可引起实质细胞坏死。Thioacetamide 通过微粒体 CYP2E1 代谢激活最初为硫代乙酰胺-S-氧化物，然后再转化为硫代乙酰胺-S-二氧化物，这是一种高度活性的代谢物，其活性代谢物与蛋白质和脂质共价结合，从而引起氧化应激和小叶中央坏死。Thioacetamide 可诱发慢性肝纤维化、脑病等事件模型。

产品详情	Thioacetamide (TAA) 是一种间接的肝毒素，可引起实质细胞坏死。Thioacetamide 通过微粒体 CYP2E1 代谢激活最初为硫代乙酰胺-S-氧化物，然后再转化为硫代乙酰胺-S-二氧化物，这是一种高度活性的代谢物，其活性代谢物与蛋白质和脂质共价结合，从而引起氧化应激和小叶中央坏死。Thioacetamide 可诱发慢性肝纤维化、脑病等事件模型。
生物活性	Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.
性状	Solid
体外研究(In Vitro)	Thioacetamide (TAA; 0-10000 μM; 24 h; WB-F344 cells) has cytotoxicity in a concentration-dependent manner. Thioacetamide (TAA; 1000 and 10000 μM; 0-24 h; WB-F344 cells) has differentially-expressed genes in the early phases at low (1000 μM) and high (10000 μM) concentrations. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	Thioacetamide (TAA; 100 mg/kg; i.p.; three times weekly) can induce chronic liver fibrosis in male ICR mice. Thioacetamide (200-1200 mg/kg; i.p.; once) induces hepatic encephalopathy model in C57BL/6 mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Wallace MC, et, al. Standard operating procedures in experimental liver research: thioacetamide model in mice and rats. Lab Anim. 2015 Apr;49(1 Suppl):21-9. [2]. Chen IS, et, al. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. J Sci Food Agric. 2012 May;92(7):1441-7.

溶解度数据	In Vitro: DMSO : 100 mg/mL (1331.03 mM; Need ultrasonic)H₂O : 50 mg/mL (665.51 mM; Need ultrasonic)配制储备液

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[1]. Wallace MC, et, al. Standard operating procedures in experimental liver research: thioacetamide model in mice and rats. Lab Anim. 2015 Apr;49(1 Suppl):21-9.
[2]. Chen IS, et, al. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. J Sci Food Agric. 2012 May;92(7):1441-7.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Thioacetamide

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