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Tribendimidine

(Synonyms: 三苯双脒)

目录号: PL07625 纯度: ≥98.0%

Tribendimidine 一种广谱的、具有口服活性的驱虫剂，对 A. lumbricoides 和 N. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。

CAS No. :115103-15-6

商品编号	规格	价格	会员价
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PL07625-10mg	10mg	¥833.00	请登录
PL07625-25mg	25mg	¥1670.00	请登录
PL07625-50mg	50mg	¥2510.00	请登录
PL07625-100mg	100mg	¥3770.00	请登录
PL07625-200mg	200mg	询价	询价
PL07625-500mg	500mg	询价	询价

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中文名称	Tribendimidine
中文别名	三苯双脒
英文名称	Tribendimidine
英文别名	Ethanimidamide,N',N'''-[1,4-phenylenebis(methylidynenitrilo-4,1-phenylene)]bis[N,N-dimethyl-;N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide;(1E,1'E)-N',N''-{benzene-1,4-diylbis[(E)methylylidenenitrilobenzene-4,1-diyl]}bis(N,N-dimethylethanimidamide);Ethanimidamide, N',N'''-(1,4-phenylenebis(methylidynenitrilo-4,1-phenylene))bis(N,N-dimethyl-;N,N'-Bis(4-(1-dimethylamino)ethylideneaminophenyl)-1,4-phenylene dimethylidyneamine;tribendimidine
Cas No.	115103-15-6
分子式	C₂₈H₃₂N₆
分子量	452.59
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Tribendimidine 一种广谱的、具有口服活性的驱虫剂，对 A. lumbricoides 和 N. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。

产品详情	Tribendimidine 一种广谱的、具有口服活性的驱虫剂，对 A. lumbricoides 和 N. americanus 具有特别高的活性。Tribendimidine 也是 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。
生物活性	Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist.
性状	Solid
体外研究(In Vitro)	Tribendimidine (100 μg/mL; 24 h) shows intoxication of C. elegans . Tribendimidine (0-100 μg/mL; 6 days) shows toxicity with an LC50 value (concentration at which half the animals are dead) of 54.4 μg/mL. Tribendimidine (0-200 μg/mL; 64 h)-induced sterility is resisted by trb mutant hermaphrodites, and Levamisole-resistant mutants are resistant to Tribendimidine. . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14. [2]. Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8.

溶解度数据	In Vitro: DMSO : 50 mg/mL (110.48 mM; ultrasonic and adjust pH to 3 with HCl)配制储备液

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[1]. Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14.
[2]. Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Tribendimidine

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