Pargyline|555-57-7|(优降宁)-陌孚医药/Medlife

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Pargyline (Synonyms: 优降宁)

目录号: PL07486 纯度: ≥99%

CAS No. :555-57-7

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中文名称	Pargyline
中文别名	帕吉林;N-甲基-N-丙炔基苄胺;N-甲基-N-炔丙基苯甲胺;N-甲基-N-炔丙基苄胺;优降宁;i>-甲基-N<;i>-炔丙基苯甲胺;N-甲基-N-(2-丙炔-1-基)苯甲胺
英文名称	Pargyline
英文别名	N-Benzyl-N-methylprop-2-yn-1-amine;Pargyline;benzyl(methyl)prop-2-ynylamine;N-Methyl-N-propargylbenzylamine;N-methyl-N-2-propyn-1-yl-Benzenemethanamine;N<;N-Methyl-N-(2-propyn-1-yl)benzylamine;benzyl-methyl-2-propinylamin;eutonyl;n-benzyl-n-methyl-2-propynylamine;n-methyl-n-2-propynylbenzylamine;Pargylin;Supirdyl;Eudatin;N-Benzyl-N-methylpropargylamine;N-Methyl-N-2-propynylbenzenemethanamine;N-Methyl-N-benzylpropynylamine;Pargylamine;Paragyline;Benzylmethylpropargylamine;Eutron;Methylbenzylpropynylamine;Pargyline [INN:BAN];MO 911;Pargylinum [INN-Latin];Pargilina [INN-Spanish];Benzenemethanamine, N-methyl-N-2-propynyl-;Pargyline chloride;BENZYLAMINE, N-METHYL-N-2-PROPYNYL;N-Benzyl-N-methyl-2-propynylamine;N-Methyl-N-2-propynylbenzylamine
Cas No.	555-57-7
分子式	C₁₁H₁₃N
分子量	159.23
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Pargyline 是一种不可逆的单胺氧化酶 (MAO) 抑制剂，对 MAO-A 和 MAO-B 的 K_i 分别为 13 μM 和 0.5 μM。Pargyline 具有降压和抗癌活性。
生物活性	Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K i s of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities.
性状	Liquid
IC50 & Target[1][2]	MAO-B 0.5 μM (Ki) MAO-A 13 μM (Ki)
体外研究(In Vitro)	Pargyline (0.5-2 mM; 24-120 hours; LNCaP-LN3 cells) treatment inhibits the proliferation of prostate cancer cells in a time- and dose-dependent manner. Pargyline (0.5-2 mM; 24-48 hours; LNCaP-LN3 cells) treatment decreases S phase and increases the G1 phase in the cells in a dose-dependent manner. Pargyline (0.5 mM; 24 hours; LNCaP-LN3 cells) treatment increases the apoptotic cells. Pargyline (2 mM; 48 hours; LNCaP-LN3 cells) treatment induces an increase of cytochrome c and a decrease of caspase-3 in the cells, but does not lead to a change of BCL-2 expression. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Pargyline (10 mg/kg; iv) treatment induces a moderate (about 20 mm Hg) but persistent (48 h) decrease of systolic blood pressure in unanesthetized adult spontaneously hypertensive rats (SHR) but not in normotensive rats. A low dose of Pargyline (200 μg; icv) injected directly into the brain lowered arterial pressure. The hypotensive action of Pargylline in SHR appears to be the consequence of Norepinephrine accumulating at an inhibitory α-adrenoceptor in brain. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. C J Fowler, et al. The nature of the inhibition of rat liver monoamine oxidase types A and B by the acetylenic inhibitors clorgyline, l-deprenyl and pargyline. Biochem Pharmacol. 1982 Nov 15;31(22):3555-61. [2]. Hyung Tae Lee, et al. Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells. Oncol Rep. 2013 Oct;30(4):1587-92.

溶解度数据	In Vitro: DMSO : 100 mg/mL (628.02 mM; Need ultrasonic)配制储备液

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