Selegiline hydrochloride|14611-52-0|(盐酸司来吉兰; Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride)-陌孚医药/Medlife

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Selegiline hydrochloride (Synonyms: 盐酸司来吉兰; Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride)

目录号: PL07490 纯度: ≥99%

CAS No. :14611-52-0

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PL07490-1g	1g	询价	询价

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中文名称	Selegiline hydrochloride
中文别名	盐酸司来吉兰;盐酸丙炔苯并胺;(R)-N,alpha-二甲基-N-(2-丙炔基)苯乙胺盐酸盐;(R)-(-)-丙炔苯丙胺盐酸盐;司来吉兰盐酸盐;司来吉米;盐酸司来吉兰 USP标准品;盐酸司来吉兰标准品;吲哚-3-甲醛肟;盐酸司来吉米;盐酸司立吉林;司来吉兰盐酸盐
英文名称	Selegiline hydrochloride
英文别名	(R)-N-Methyl-N-(1-phenylpropan-2-yl)prop-2-yn-1-amine hydrochloride;R-(-)-Deprenyl hydrochloride;(R)-(-)-N,alpha-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride;Selegiline hydrochloride;(R)-(-)-Deprenyl hydrochloride;R-(-)-Deprenyl (hydrochloride);R(-)-Deprenyl hydrochloride;(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine,hydrochloride;L-Deprenyl hydrochloride;R-(?)-Deprenyl hydrochloride;Selegiline HCl;(R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride;R-(−)-Deprenyl hydrochloride;R(−)-N-α-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride;jumex;FP-OD;fpf1100;Amindan;Anipryl;eldepryl;Movergan;Plurimen;Eldeprine;SELEGILINE
Cas No.	14611-52-0
分子式	C₁₃H₁₇N^.HCl
分子量	223.74
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Selegiline (Deprenyl) hydrochloride 是一种有效、选择性和不可逆的 MAO-B 抑制剂，IC₅₀ 值为 51 nM。Selegiline hydrochloride 对 MAO-B 的选择性比 MAO-A 高 450 倍 (IC₅₀=23 μM)。Selegiline hydrochloride 可用于帕金森氏病、阿尔茨海默病和重度抑郁症的研究。
生物活性	Selegiline (Deprenyl) hydrochloride is a potent, selective and irreversible inhibitor of MAO-B, with an IC 50 of 51 nM. Selegiline hydrochloride exhibits 450-flod selectivity for MAO-B over MAO-A (IC 50 =23 μM). Selegiline hydrochloride can be used for the research of Parkinsons disease, Alzheimers disease and major depressive disorder.
性状	Solid
IC50 & Target[1][2]	MAO-B 51 nM (IC50)
体外研究(In Vitro)	Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner. Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Chaurasiya ND, et, al. Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana). Molecules. 2019 Feb 23;24(4):810. [2]. Tatton WG, et, al. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. 1996 Dec;47(6 Suppl 3):S171-83.

溶解度数据	In Vitro: DMSO : 200 mg/mL (893.89 mM; Need ultrasonic)H₂O : ≥ 33.33 mg/mL (148.97 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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