MAO-IN-M30 dihydrochloride|64821-19-8|-陌孚医药/Medlife

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MAO-IN-M30 dihydrochloride

目录号: PL07477 纯度: ≥99%

CAS No. :64821-19-8

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中文名称	MAO-IN-M30 dihydrochloride
中文别名	5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol,dihydrochloride
英文名称	MAO-IN-M30 dihydrochloride
英文别名	5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride;M-30 dihydrochloride;VAR10300 dihydrochloride;MAO-IN-M30 dihydrochloride;M30 (dihydrochloride);M 30 dihydrochloride;M30 dihydrochloride, >=98% (HPLC);5-[[methyl(prop-2-ynyl)amino]methyl]quinolin-8-ol;dihydrochloride;5-((Methyl(prop-2-yn-1-yl)amino)methyl)quinolin-8-ol dihydrochloride;5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride;N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride;5-{[Methyl(prop-2-yn-1-yl)amino]methyl}quinolin-8-ol--hydrogen chloride
Cas No.	64821-19-8
分子式	C₁₄H₁₆Cl₂N₂O
分子量	299.20
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	MAO-IN-M30 dihydrochloride 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC₅₀=37 nM) 和 MAO-B (IC₅₀=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
生物活性	MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC 50 =37 nM) and MAO-B (IC 50 =57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinsons disease.
性状	Solid
IC50 & Target[1][2]	MAO-A 37 nM (IC50) MAO-B 57 nM (IC50
体外研究(In Vitro)	MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone. MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival. MAO-IN-M30 treatment significantly decreases the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay
体内研究(In Vivo)	MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57/BL mice (20-22 g; M
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Gal S, et al. M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinsons disease. J Neural Transm Suppl. 2006;(70):447-456. [2]. Zheng H, et al. Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J Neur

溶解度数据	In Vitro: DMSO : 2 mg/mL (6.68 mM; ultrasonic and warming and heat to 60°C)配制储备液

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