(S)-Thalidomide|841-67-8|-陌孚医药/Medlife

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(S)-Thalidomide

目录号: PL07456 纯度: ≥99%

CAS No. :841-67-8

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中文名称	(S)-Thalidomide
中文别名	(S)-(-)-沙利度胺;(-)-萨立多胺;(-)-沙利度胺;(?)-沙利度胺;S-沙利度胺
英文名称	(S)-Thalidomide
英文别名	1H-Isoindole-1,3(2H)-dione,2-[(3S)-2,6-dioxo-3-piperidinyl]-;(S)-(-)-Thalidomide;(-)-(S)-1,3-dioxo-2-(2',6'-dioxopiperidin-3'-yl;(-)-N-[(S)-2,6-Dioxo-3-piperidinyl]phthalimide;(-)-THALIDOMIDE &N-[(S)-2,6-Dioxopiperidine-3-yl]phthalimide;(3S)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione;2-[(3S)-2,6-Dioxo-3-piperidyl]-1H-isoindole-1,3(2H)-dione;6-dioxo-3-piperidinyl)-3(2h)-dion(s)-1h-isoindole-2-(2;6-dioxo-3-piperidyl)-n-(l-(-)-phthalimid;L-thalidomide;S(-)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE;(S)-Thalidomide
Cas No.	841-67-8
分子式	C₁₃H₁₀N₂O₄
分子量	258.23
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S-对映体。(S)-Thalidomide 具有免疫调节，抗炎，抗血管生成和促凋亡作用。(S)-Thalidomide 通过与 cereblon (CRBN) 结合诱导致畸作用。
生物活性	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects. (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .
性状	Solid
IC50 & Target[1][2]	Apoptosis
体外研究(In Vitro)	(S)-Thalidomide treatment results in a reduction in cell viability in U266 cells with an IC50 of 362 μM. (S)-Thalidomide treatment increased apoptosis in a dose-dependent manner in U266 cells. There are changes in the expression profile of genes involved in angiogenesis and apoptosis, but the changes are most dramatic in the apoptotic genes. In particular, the expression of I-κB kinase is decreased by two-fold, which is associated with a four-fold decrease in NF-κB expression. (S)-Thalidomide increases the Bax:Bcl-2 ratio, also increases I-kB protein levels, and decreases NF-kB activity. A dramatic decrease in Bcl-2 expression with (S)-Thalidomide suggests a possible enhancement of cytotoxic effect if combined with other cytotoxic agents. has not independently confirmed the accuracy of these methods.
体内研究(In Vivo)	Thalidomide does cause limb reduction defects in chick embryos as long as the embryos are directly exposed to the drug. The most useful techniques are implanting Thalidomide-soaked beads into the embryo immediately adjacent to the limb territory or soaking presumptive chick limb territories in Thalidomide and then grafting the explants to a host embryo celom. Thalidomide affects the chick limb grafted to a host embryo in a dose response fashion. Furthermore, (S)-Thalidomide is more teratogenic than (R)-Thalidomide. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Liu WM, et al. s-thalidomide has a greater effect on apoptosis than angiogenesis in a multiple myeloma cell line. Hematol J. 2004;5(3):247-54. [2]. Stephens TD. The effect of thalidomide in chicken embryos. Birth Defects Res A Clin Mol Teratol. 2009 Aug;85(8):725-31. [3]. Murphy S, et al. Enantioselectivity of

溶解度数据	In Vitro: DMSO : 83.33 mg/mL (322.70 mM; Need ultrasonic)配制储备液

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