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产品总数：61445
| 商品编号 | 规格 | 价格 | 会员价 | 是否有货 | 数量 |
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| PL04388-5mg | 5mg | ¥492.00 | 请登录 |
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| PL04388-10mg | 10mg | ¥742.00 | 请登录 |
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| PL04388-50mg | 50mg | ¥1675.00 | 请登录 |
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| PL04388-100mg | 100mg | ¥2525.00 | 请登录 |
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| PL04388-200mg | 200mg | 询价 | 询价 |
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| PL04388-500mg | 500mg | ¥5955.00 | 请登录 |
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| PL04388-10mM*1mLinDMSO | 10mM*1mLinDMSO | ¥1134.00 | 请登录 |
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| PL04388-1 mL x 10 mM (in DMSO) | ¥580.00 | 请登录 |
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| 中文名称 |
Tenofovir alafenamide hemifumarate
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|---|---|
| 中文别名 |
替诺福韦艾拉酚胺半富马酸盐;GS7340半富马酸盐;2,3-二氢-5-氨基-6-氯异吲哚酮;GS-7340半富马酸;替诺福韦艾拉芬胺半富马酸盐;替诺福韦艾拉酚胺富马酸盐;替诺福韦艾拉酚胺富马酸;替诺福韦艾拉酚胺富马酸半盐;替诺福韦艾拉芬胺半富马酸;(S)-丙胺酸异丙酯2-{(S)-[((R)-1-(6-氨基-9H-嘌呤-9-基)-1-甲基乙氧基]甲基}-苯氧基磷酰基半反丁烯二酸盐;替诺福韦-富马酸阿芬烯胺[ USAN ];替诺福韦艾拉芬胺;富马酸磷丙替诺福韦
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| 英文名称 |
Tenofovir alafenamide hemifumarate
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| 英文别名 |
GS7340（Tenofovir Alafenamide Fumarate）;GS-7340 Hemifumarate;Tenofovir alafenamide fumarate, 2:1;L-Alanine,N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinyl)-,1-methylethyl ester,(2E)-2-butenedioate (2:1);GS-7340-03;1-Methylethyl N-((S)-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phenoxyphosphinoyl)-L-alaninate,(2E)-2-butenedioate;(E)-but-2-enedioic acid,propan-2-yl (2S)-2-[[1-(6-aminopurin-9-yl)propan-2-yloxymethyl-phenoxyphosphoryl]amino]propanoate;(S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate fumarate(2:1);Tenofovir Alafenamide Fumarate;Tenofovir alafenamide fumarate(2:1);GS7340 hemifumarate;Tenofovir alafenamide hemifumarate;N-[(S)-[[(1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-L-alanine 1-methylethyl ester (2E)-2-butenedioate (2:1);GS 7340-03;GS-7340 (hemifumarate);L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester, (2E)-2-butenedioate (2:1);TENOFOVIR ALAFENAMIDE HEMIFUMARATE (GS-7340 HEMIFUMARATE);Tenofovir levamide amine fumarate;GS7340(Tenofovir Alafenamide Fumarate);(Tenofovir alafenamide : fumarate = 2:1);Anti-HIV
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| Cas No. |
1392275-56-7
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| 分子式 |
2[C21H29N6O5P].C4H4O4
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| 分子量 |
1069.00
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| 包装储存 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| 详情描述 |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 Tenofovir 的前体，Tenofovir 是一种 HIV-1 核苷酸逆转录酶抑制剂。
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| 产品详情 |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 Tenofovir 的前体，Tenofovir 是一种 HIV-1 核苷酸逆转录酶抑制剂。
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| 生物活性 |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
HIV-1 HIV-2
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| 体外研究(In Vitro) |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 体内研究(In Vivo) |
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) . has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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| ClinicalTrial |
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| 参考文献 |
[1]. Birkus G, et al. Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors. Antimicrob Agents Chemother. 2015 Oct 26;60(1):316-22.[2]. Callebaut C, et al. In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate. Antimicrob Agents Chemother. 2015 Oct;59(10):5909-16.
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| 溶解度数据 |
In Vitro: DMSO : 50 mg/mL (93.55 mM; Need ultrasonic)H2O : 20 mg/mL (37.42 mM; ultrasonic and warming and heat to 60°C)配制储备液
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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