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DAPTA

(Synonyms: D-Ala-peptide T-amide; Adaptavir)

目录号: PL05800 纯度: ≥98%

DAPTA 是一种合成肽，为 CCR5 抑制剂，同时具有抗 HIV 的活性。

CAS No. :106362-34-9

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中文名称	DAPTA
中文别名	(D-ALA1)-PEPTIDE T AMIDE
英文名称	DAPTA
英文别名	L-Threoninamide,D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;(D-ALA1)-PEPTIDE T AMIDE;(D-Ala1)-Peptide T amide, DAPTA;[D-Ala1] Peptide T, amide;DAPTA;H-D-ALA-SER-THR-THR-THR-ASN-TYR-THR-NH2;Adaptavir;ASTTTNYT;D-Ala-L-Ser-L-Thr-L-Thr-L-Thr-L-Asn-L-Tyr-L-Thr-NH2;D-Ala-peptide T-amide;D-ala-ser-thr-thr-thr-asn-tyr-thr amide acetate;D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr amide acetate salt;D-ALA-SER-THR-THR-THR-ASN-TYR-THR-NH2;L-ThreoninaMide,D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl;Octapeptide T;(D-Ala1)-Peptide T aMide DAPTA;L-ThreoninaMide, D-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-;RAP101;J208V4ZMP2;mDAPTA;monomeric D-Ala-peptide;[D-Ala1] Peptide T Amide;D-Ala1-peptide T-amide;(D-Alanine1)Peptide T amide;Monomeric DAPTA;D-Ala1-peptide T-NH2;(D-ALA1)-PEPTIDETAMIDE;monome
Cas No.	106362-34-9
分子式	C₃₅H₅₆N₁₀O₁₅
分子量	856.88
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
详情描述	DAPTA 是一种合成肽，为 CCR5 抑制剂，同时具有抗 HIV 的活性。

产品详情	DAPTA 是一种合成肽，为 CCR5 抑制剂，同时具有抗 HIV 的活性。
生物活性	DAPTA is a synthetic peptide, functions as a viral entry inhibitor by targeting selectively CCR5, and shows potent anti-HIV activities.
性状	Solid
IC50 & Target[1][2]	gp120BaL/sCD4-CCR5 55 pM (IC50, in Cf2Th/synR5 cells) gp120CMCM235/sCD4-CCR5
体外研究(In Vitro)	DAPTA (1 nM) inhibits HIV-1 replication in monocytes/macrophages (M/M) by >90%. DAPTA blocks HIV entry and prevents HIV-1 infection. DAPTA reduces CCR5 mAb binding in human primary macrophages. DAPTA potently blocks R5 gp120-mediated neuronal apoptosis. DAPTA is even more potent in preventing neuronal apoptosis than the CCR5 antagonist TAK-779. DAPTA potently inhibits specific CD4-dependent binding of gp120 Bal (IC50 = 0.06 nM) and CM235 (IC50 = 0.32 nM) to CCR5. DAPTA (1 nM) blocks formation of the gp120/sCD4 complex with CCR5. DAPTA inhibits the binding of gp120BaL/sCD4 to CCR5 (Cf2Th/synR5) cells with IC50 of 55 ± 0.08 pM. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	ASTTTNYT-NH2
Sequence	Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH2
参考文献	[1]. Pollicita M, et al. Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells. Antivir Chem Chemother. 2007;18(5):285-95. [2]. Polianova MT, et al. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 Aug;67(2):83-92.

溶解度数据	In Vitro: H₂O : 50 mg/mL (58.35 mM; Need ultrasonic)配制储备液

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[1]. Pollicita M, et al. Profound anti-HIV-1 activity of DAPTA in monocytes/macrophages and inhibition of CCR5-mediated apoptosis in neuronal cells. Antivir Chem Chemother. 2007;18(5):285-95.
[2]. Polianova MT, et al. Chemokine receptor-5 (CCR5) is a receptor for the HIV entry inhibitor peptide T (DAPTA). Antiviral Res. 2005 Aug;67(2):83-92.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

DAPTA

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