Apoptozole|1054543-47-3|(Apoptosis Activator VII)-陌孚医药/Medlife

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Apoptozole (Synonyms: Apoptosis Activator VII)

目录号: PL04348 纯度: ≥99%

CAS No. :1054543-47-3

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中文名称	Apoptozole
中文别名	4-[[2-[3,5-二(三氟甲基)苯基]-4,5-二(4-甲氧基苯基)-1H-咪唑-1-基]甲基]苯甲酰胺;Apoptozole
英文名称	Apoptozole
英文别名	BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;4-({2-[3,5-Bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1 H-imidazol-1-yl}methyl)benzamide;Apoptozole;Apoptosis Activator VII, Apoptozole;6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1);Apoptosis Activator VII;4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl]methyl]benzamide;4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl)methyl)benzamide;BCP18667;s8365;AK685531;Benzamide, 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-
Cas No.	1054543-47-3
分子式	C₃₃H₂₅F₆N₃O₃
分子量	625.56
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Apoptozole (Apoptosis Activator VII) 是 Hsc70 和 Hsp70 的 ATPase 结构域抑制剂，可诱导凋亡，K_d 值分别为 0.21 和 0.14 μM。
生物活性	Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with K d s of 0.21 and 0.14?μM, respectively, and can induce apoptosis.
性状	Solid
IC50 & Target[1][2]	HSP70 0.14 μM (Kd) HSC70 0.21 μM (Kd)
体外研究(In Vitro)	Apoptozole is an inhibitor of Hsc70 and Hsp70, which binds to Hsc70 and Hsp70, with Kds of 0.21 and 0.14?μM, respectively. Apoptozole (Apoptosis Activator VII; 1?μM) induces apoptosis in P19 cells. Apoptozole shows inhibitory activities against several cancer cell lines, such as SK-OV-3 (ovarian cancer cells), HCT-15 (colon cancer cells), and A549 (lung cancer cells), with IC50s of 0.22, 0.25, and 0.13?μM, respectively. Apoptozole binds to the ATPase domain of Hsc70 and Hsp70, but does not binds to other types of heat shock proteins such as Hsp60, Hsp90 or Hsp40. Apoptozole (0-15 μM) suppresses the growth of A549 cells, HeLa cells, and MDA-MB-231 cells, with IC50s ranging from 5 to 7 μM. Apoptozole (5 or 10 μM) shows no effect on associations of HSP70 with ASK1, JNK, or BAX, and does not induce AIF-mediated caspase-independent apoptosis in HeLa
体内研究(In Vivo)	Apoptozole (Apoptosis Activator VII; 4 mg/kg, i.p.) exhibits antitumor activities in nude mice xenografted with A549, RKO (colorectal carcinoma), and HeLa cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Williams DR, et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew Chem Int Ed Engl. 2008;47(39):7466-9. [2]. Cho HJ, et al. Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis. Mol Biosyst. 2015 Oct;11(10):2763-9. [3]. Ko SK, et al.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (159.86 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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