KRIBB11|342639-96-7|-陌孚医药/Medlife

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KRIBB11

目录号: PL01142 纯度: ≥99%

CAS No. :342639-96-7

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中文名称	KRIBB11
中文别名	N2-1H-吲唑-5-基-N6-甲基-3-硝基-2,6-吡啶二胺;KRIBB11
英文名称	KRIBB11
英文别名	KRIBB11;KRIBB-11;N2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;BCP19297;s8402;BDBM50114871;AK685532;A16347;N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine;N-(1H-Indazole-5-yl)-N'-methyl-3-nitropyridine-2,6-diamine;2-N-(1H-indazol-5-yl)-6-N-methyl-3-nitropyridine-2,6-diamine;KRIBB 11
Cas No.	342639-96-7
分子式	C₁₃H₁₂N₆O₂
分子量	284.27
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	KRIBB11 是 HSF1 的抑制剂，IC₅₀ 值为 1.2 μM。
生物活性	KRIBB11 is an inhibitor of Heat shock factor 1 (HSF1), with IC 50 of 1.2 μM.
性状	Solid
IC50 & Target[1][2]	HSF1 1.2 μM (IC50)
体外研究(In Vitro)	KRIBB11 blocks the induction of HSF1 downstream target proteins such as HSP27 and HSP70. KRIBB11 induces growth arrest and apoptosis of HCT-116 cells. KRIBB11 inhibits HSF1-dependent recruitment of p-TEFb (positive transcription elongation factor b) to the hsp70 promoter. PARP and caspase-3 cleavage is increased in cells treated with KRIBB11. Incubating RKO with KRIBB11, shows a toxic threshold of about 10 μM, and an IC50 of 20-30 μM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	KRIBB11 (50 mg/kg, i.p.) results in a 47.4% inhibition of tumor growth in nude mice, without body weight loss. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Yoon YJ, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011 Jan 21;286(3):1737-47 [2]. Samarasinghe B, et al. Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux. Biochem Pharmacol. 2014 Feb 1;87(3):445-55

溶解度数据	In Vitro: DMSO : ≥ 27 mg/mL (94.98 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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