Quinagolide hydrochloride|94424-50-7|(盐酸喹高利特; CV205-502 hydrochloride)-陌孚医药/Medlife

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Quinagolide hydrochloride (Synonyms: 盐酸喹高利特; CV205-502 hydrochloride)

目录号: PL03671

CAS No. :94424-50-7

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中文名称	Quinagolide hydrochloride
中文别名	盐酸喹高莱;(3S,4aS,10aR)-3-(二乙基氨磺酰氨基)-6-羟基-1-丙基-3,4,4a,5,10,10a-六氢-2H-苯并[g]喹啉盐酸盐;2-甲基屈;盐酸硅高利特;盐酸喹高利特
英文名称	Quinagolide hydrochloride
英文别名	Quinagolide hydrochloride;(3S,4aS,10aR)-3-(Diethylsulfamoylamino)-6-hydroxy-1-propyl-3,4,4a,5,10,10a-hexahydro-2H-benzo[g]quinoline hydrochloride;CV205-502 hydrochloride;Quinagolide Hydrochl;Norprolac;Norprolac (TN);Quinagolide HCl;Quinagolide hydrochloride (BAN);Benzo[g]quinoline, sulfamide deriv. (ZCI);Sulfamide, N,N-diethyl-N′-(1,2,3,4,4a,5,10,10a-octahydro-6-hydroxy-1-propylbenzo[g]quinolin-3-yl)-, monohydrochloride, (3α,4aα,10aβ)-(±)- (ZCI);Sulfamide, N,N-diethyl-N′-[(3R,4aR,10aS)-1,2,3,4,4a,5,10,10a-octahydro-6-hydroxy-1-propylbenzo[g]quinolin-3-yl]-, monohydrochloride, rel- (9CI);Sulfamide, N,N-diethyl-N′-(1,2,3,4,4a,5,10,10a-octahydro-6-hydroxy-1-propylbenzo[g]quinolin-3-yl)-, monohydrochloride, (3α,4aα,10aβ)-
Cas No.	94424-50-7
分子式	C₂₀H₃₄ClN₃O₃S
分子量	432.02
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Quinagolide hydrochloride (CV205-502 hydrochloride) 是选择性的、具有口服活性的多巴胺 D2 受体激动剂。Quinagolide hydrochloride 是催乳素抑制剂。Quinagolide hydrochloride 下调 AKT 的水平及其磷酸化。Quinagolide hydrochloride 具有抗肿瘤活性，可用于癌症的研究。

生物活性

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer.

性状

Solid

体外研究(In Vitro)

Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines.
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs).
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs. has not independently confirmed the accuracy of these methods. They are for reference only.Western B

体内研究(In Vivo)

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Wistar-Furth

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Trouillas J, et al. Inhibitory effects of the dopamine agonists quinagolide (CV 205-502) and bromocriptine on prolactin secretion and growth of SMtTW pituitary tumors in the rat. Endocrinology. 1994 Jan;134(1):401-10.
[2]. Iampietro C, et al. Quinagolide Treatment Reduces Invasive and Angiogenic Properties of Endometrial Mesenchymal Stromal Cells. Int J Mol Sci. 2022 Feb 4;23(3):1775.

溶解度数据	In Vitro: DMSO : 3.85 mg/mL (8.91 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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