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LM22B-10

目录号: PL01480 纯度: ≥99%

LM22B-10 是一种 TrkB/TrkC 神经营养因子受体激活剂，能够诱导体内体外 TrkB，TrkC，AKT 和 ERK 的活化。

CAS No. :342777-54-2

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中文名称	LM22B-10
中文别名	LM22B-10
英文名称	LM22B-10
英文别名	LM22B-10;CBMicro_004706;QCXQLSGBOUUVNH-UHFFFAOYSA-N;SMSF0003215;BCP30139;LM22B 10;ZB0041;CB07009;AK00792418;4,4'-(4-Chlorobenzylidene)bis[N,N-bis(2-hydroxyethyl)aniline];2,2',2',2'''-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol;2-{[4-({4-[bis(2-hydroxyethyl)amino]phenyl}(4-chlorophenyl)methyl)phenyl](2-hydroxyeth;2-[4-[[4-[Bis(2-hydroxyethyl)amino]phenyl]-(4-chlorophenyl)methyl]-N-(2-hydroxyethyl)anilino]ethanol
Cas No.	342777-54-2
分子式	C₂₇H₃₃ClN₂O₄
分子量	485.01
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	LM22B-10 是一种 TrkB/TrkC 神经营养因子受体激活剂，能够诱导体内体外 TrkB，TrkC，AKT 和 ERK 的活化。

产品详情	LM22B-10 是一种 TrkB/TrkC 神经营养因子受体激活剂，能够诱导体内体外 TrkB，TrkC，AKT 和 ERK 的活化。
生物活性	LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
性状	Solid
IC50 & Target[1][2]	TrkB TrkC
体外研究(In Vitro)	LM22B-10 exhibits maximum neurotrophic survival activity levels that are higher than those maximally achieved with BDNF (53 ± 7.2% above BDNF at 0.7 nM) and NT-3 (91 ± 8.6% above NT-3 at 0.7 nM) with an EC50 value of 200-300 nM. LM22B-10 (1000 nM) induces neurites of significantly larger average lengths, up to -40 μM. LM22B-10 (250-2000 nM) binds to TrkB-Fc and TrkC-Fc in a dose-dependent manner. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells. LM22B-10 promotes cell survival and functions preferentially through TrkB and TrkC. LM22B-10, but not BDNF or NT-3, promotes neurite outgrowth in an inhibitory environment. LM22B-10 induces patterns of Trk and downstream signaling activation that are distinct from those of BDNF and NT-3. LM22B-10 also induces TrkB, TrkC, AKT and ERK activation in hippocampal neurons in culture.
体内研究(In Vivo)	LM22B-10 (0.5 mg/kg) activates TrkB, TrkC, AKT and ERK in C57BL/6J mice. LM22B-10 (50 mg/kg, i,p,) shows increased phosphorylation at TrkB and TrkC. LM22B-10 activates synaptic TrkB and TrkC and increases pre- and post-synaptic proteins and spine density in aged mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110(Pt A):343-61.

溶解度数据	In Vitro: DMSO : ≥ 150 mg/mL (309.27 mM)配制储备液

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[1]. Yang T, et al. A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. Neuropharmacology. 2016 Nov;110(Pt A):343-61.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

LM22B-10

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