Seco-DUBA|1227961-59-2|-陌孚医药/Medlife

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Seco-DUBA

目录号: PL03271 纯度: ≥95%

CAS No. :1227961-59-2

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中文名称	Seco-DUBA
中文别名	SECO-DUBA
英文名称	Seco-DUBA
英文别名	Benzamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxy-;Seco-DUBA
Cas No.	1227961-59-2
分子式	C₂₉H₂₃ClN₄O₄
分子量	526.97
包装储存	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	Seco-DUBA 是一种多卡霉素 (DUBA) 的前药，含有两个羟基，每个羟基都可以通过连接剂与抗体偶联。Seco-DUBA 可用于合成抗体-药物结合物 (ADCs)。
生物活性	Seco-DUBA is a duocarmycin (DUBA) prodrug containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).
性状	Solid
体外研究(In Vitro)	Seco-DUBA (SK-BR-3 cells; 0.0001 pM~0.01 nM; 144 hours) dose-dependent reduces cell viability and shows equally potent and efficacious as DUBA. Seco-DUBA causes SK-BR-3 (IC50=0.09), SK-OV-3 (IC50=0.43), and SW620 (IC50=0.09) cells to exhibit highly sensitive. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Cytotoxicity Assay
体内研究(In Vivo)	Seco-DUBA (89 μg/kg; i.v.) is likely converted to DUBA almost instantaneously. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Wistar rats
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Elgersma RC, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015;12(6):1813-1835. [2]. Platform Technologies in Drug Discovery and Validation

溶解度数据	In Vitro: DMSO : 100 mg/mL (189.76 mM; ultrasonic and warming and heat to 60°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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