Lenacapavir (Synonyms: GS-6207)
目录号: PL01974 纯度: ≥98%
CAS No. :2189684-44-2
商品编号 规格 价格 会员价 是否有货 数量
PL01974-5mg 5mg ¥1366.00 请登录
PL01974-10mg 10mg ¥2185.00 请登录
PL01974-25mg 25mg ¥4420.00 请登录
PL01974-50mg 50mg ¥6670.00 请登录
PL01974-100mg 100mg ¥9965.00 请登录
PL01974-200mg 200mg 询价 询价
PL01974-500mg 500mg 询价 询价
Medlife所售产品仅用于科学研究(非临床研究),非药品不可食用,不可用于人体或动物的临床诊断和治疗,我们不为个人提供产品及服务。产品COA等资料,可至下方“质量控制”中下载。
中文名称
Lenacapavir
英文名称
Lenacapavir
英文别名
A9A0O6FB4H;GS-CA1;N-[(1S)-1-[3-[4-chloro-3-(methanesulfonamido)-1-(2,2,2-trifluoroethyl)indazol-7-yl]-6-(3-methyl-3-methylsulfonyl-but-1-ynyl)-2-pyridyl]-2-(3,5-difluorophenyl)ethyl]-2-[difluoro(trifluoromethyl)[?]yl]acetamide;N-((S)-1-(3-(4-Chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifl;Unii-A9A0O6FB4H;GS-6207;Lenacapavir
Cas No.
2189684-44-2
分子式
C39H32ClF10N7O5S2
分子量
968.28
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
Lenacapavir (GS-6207) 是一种 HIV-1 衣壳抑制剂。在 MT-4 细胞中,Lenacapavir 具有抗 HIV 活性,EC50 为 100 pM,在外周血单个核细胞中,对 23 种来自不同亚型的 HIV-1 临床分离株的平均 EC50 为 50 pM (20-160 pM)。
生物活性
Lenacapavir (GS-6207) is a HIV-1 capsid inhibitor. Lenacapavir shows anti-HIV activity with an EC 50 of 100 pM in MT-4 cells. Lenacapavir displays a mean EC 50 of 50 pM (20-160 pM) against 23 HIV-1 clinical isolates from different subtypes in peripheral blood mononuclear cells (PBMCs).
性状
Solid
IC50 & Target[1][2]
EC50: 100 pM (anti-HIV; in MT-4 cells)
体外研究(In Vitro)
Lenacapavir (GS-6207) is a potent capsid-targeting inhibitor of HIV replication. Lenacapavir shows sub-nanomolar potency in target cells (EC50=23 pM), in a full-cycle assay (EC50=25 pM) and in producer cells (EC50=439 pM). Lenacapavir interferes with both the early and late stages of HIV-1 replication but exhibits greater potency against the early stage. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Singh K, et al. GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds. Front Microbiol. 2019 Jun 20;10:1227.
[2]. John O Link, et al. Clinical targeting of HIV capsid protein with a long-acting small molecule. Nature. 2020 Jul 1.
溶解度数据
In Vitro: DMSO : 200 mg/mL (206.55 mM; Need ultrasonic)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2