Desisobutyryl-ciclesonide|161115-59-9|(去异丁基环索奈德; CIC-AP; Ciclesonide active principle)-陌孚医药/Medlife

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Desisobutyryl-ciclesonide (Synonyms: 去异丁基环索奈德; CIC-AP; Ciclesonide active principle)

目录号: PL01922 纯度: ≥95%

CAS No. :161115-59-9

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中文名称	Desisobutyryl-ciclesonide
中文别名	去异丁酸酯环索奈德;去异丁基环索奈德;21 去isobutyryl环索奈德;2-氯-4,6-二苯基-1,3,5-三嗪;环索奈德杂质B;去异丁酰基环索奈德;环索奈德EP杂质B
英文名称	Desisobutyryl-ciclesonide
英文别名	Desisobutyryl Ciclesonide;B-9207-021;CIC-AP;Ciclesonide active principle;Ciclesonide impurity B;Des-CIC;desisobutyryl-ciclesonide;21-Desisobutyryl Ciclesonide;(11β,16α)-16,17-[[(R)-CyclohexylMethylene]bis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione;(2′R)-2′-Cyclohexyl-11b,21-dihydroxy-16bH-[1,3]dioxolo[4′,5′:16,17]pregna-1,4-diene-3,20-dione
Cas No.	161115-59-9
分子式	C₂₈H₃₈O₆
分子量	470.60
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Desisobutyryl-ciclesonide 是 Ciclesonide 的活性代谢产物。Desisobutyryl-ciclesonide 对糖皮质激素受体 (glucocorticoid receptor) 具有亲和力。
生物活性	Desisobutyryl-ciclesonide is the active metabolite of Ciclesonide. Desisobutyryl-ciclesonide has affinity for the glucocorticoid receptor.
性状	Solid
IC50 & Target[1][2]	Glucocorticoid receptor
体外研究(In Vitro)	Ciclesonide, an inhaled corticosteroid with almost no affinity for the glucocorticoid receptor, is highly effective in downregulating in vitro pro-inflammatory activities of airway parenchymal cells when converted into the active metabolite Desisobutyryl-ciclesonide. Peripheral blood mononuclear cell proliferation to C. albicans is dose-dependently inhibited by 0.3-3.0 μM Ciclesonide and Desisobutyryl-ciclesonide but inhibition by Desisobutyryl-ciclesonide is higher. A significant proliferation to PhlP5 is observed only in cultures from atopic subjects: an effective downregulation is already detected at 0.03 μM Ciclesonide and 0.003 μM Desisobutyryl-ciclesonide (complete inhibition at 3 μM Ciclesonide and 0.03 μM Desisobutyryl-ciclesonide). 3 μM Ciclesonide and Desisobutyryl-ciclesonide reduce the PhlP5 -specific T-cell blast proliferation and interleukin 4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Silvestri M, et al. Ciclesonide modulates in vitro allergen-driven activation of blood mononuclear cells and allergen-specific T-cell blasts. Immunol Lett. 2012 Jan 30;141(2):190-6.

溶解度数据	In Vitro: DMSO : 100 mg/mL (212.49 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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