AZD2906|1034148-15-6|-陌孚医药/Medlife

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AZD2906

目录号: PL02157 纯度: ≥99%

CAS No. :1034148-15-6

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中文名称	AZD2906
英文名称	AZD2906
英文别名	AZD2906;N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(6-methoxypyridin-3-yl)propan-2-yl)cyclopropanecarboxamide;n-[(1r,2s)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide;GTPL11780;BDBM50203422;compound 4 [PMID: 29424542];B9Q
Cas No.	1034148-15-6
分子式	C₂₆H₂₅FN₄O₃
分子量	460.50
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	AZD2906 为一种选择性的糖皮质激素受体 glucocorticoid receptor (GR) 激动剂，能够增加大鼠骨髓中的微核未成熟红细胞。AZD290 对人、大鼠 PBMC 和全血中 GR 的 IC₅₀ 值分别为 2.2，0.3，41.6 和 7.5 nM。
生物活性	AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC 50 s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively.
性状	Solid
IC50 & Target[1][2]	IC50: 2.2 nM (Glucocorticoid receptor, Human PBMC), 0.3 nM (Glucocorticoid receptor, Rat PBMC), 41.6 nM (Glucocorticoid receptor, Human whole blood), 7.5 nM (Glucocorticoid receptor, Rat whole blood)
体外研究(In Vitro)	AZD2906 is a selective glucocorticoid receptor (GR), with IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	AZD2906 (5, 25, 50 mg/kg, p.o.) increases micronucleated immature erythrocytes (MIE) in the bone marrow of rats after treatment for 2 days. AZD2906 (5, 25 mg/kg, p.o.) induces an accumulation of glycogen in the liver of rats, and exhibits cortical lymphocytic atrophy of a moderate to marked degree in the thymus of rats. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Hayes JE, et al. Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. I: glucocorticoid receptor agonism. Mutagenesis. 2013 Mar;28(2):227-32.

溶解度数据	In Vitro: DMSO : 125 mg/mL (271.44 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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