5-Fluorouridine 是 5-fluorouracil (HY-90006) 的代谢物，是一种有效的核酶自裂解抑制剂。5-Fluorouridine 可与总和多 A RNA 结合，具有抗增殖活性。5-Fluorouridine 诱发细胞凋亡 (apoptosis)。

5-Fluorouridine, a metabolite of 5-fluorouracil (HY-90006), is a potent ribozyme self-cleavage inhibitor. 5-Fluorouridine incorporates into both total and poly A RNA and has antiproliferative activity. 5-Fluorouridine induces apoptosis.

Solid

5-Fluorouridine (167 μM; 24-96 h) inhibits MKN45 cells and MKN28 cells in a time-dependent manner.
5-Fluorouridine (10 μM; 24 h; HCT-116 cells) induces apoptosis and increases the percentage of apoptotic cells. 5-Fluorouridine upregulates the expression of 33 genes, including a group of genes as growth factors, cytokines and chemokines (e.g. IL-3, IL -4, B-cell growth factor 1 and stem cell growth factor).
5-Fluorouridine (10 μM; 8-24 h; HCT-116 cells) incorporates into both total and poly A RNA.
has not independently confirmed the accuracy of these methods. They are for reference only.

5-Fluorouridine (567-1500 mg/kg; i.p.; daily, for 20 d) induce gastrointestinal toxicity in the mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male CBA/J mice (17-20 g; 6-8 wee

Room temperature in continental US; may vary elsewhere.

4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

[1]. Wu FL, et, al. Gelatinases-stimuli nanoparticles encapsulating 5-fluorouridine and 5-aza-2-deoxycytidine enhance the sensitivity of gastric cancer cells to chemical therapeutics. Cancer Lett. 2015 Jul 10;363(1):7-16.
[2]. Schmittgen TD, et, al. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Int J Oncol. 2005 Aug;27(2):297-306.

In Vitro: H₂O : 100 mg/mL (381.40 mM; Need ultrasonic)DMSO : ≥ 100 mg/mL (381.40 mM)