Phenserine|101246-66-6|((-)-Eseroline phenylcarbamate; (-)-Phenserine)-陌孚医药/Medlife

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Phenserine (Synonyms: (-)-Eseroline phenylcarbamate; (-)-Phenserine)

目录号: PL01406 纯度: ≥99%

CAS No. :101246-66-6

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中文名称	Phenserine
中文别名	苯丝氨酸
英文名称	Phenserine
英文别名	Pyrrolo[2,3-b]indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-phenylcarbamate), (3aS,8aR)-;Phenserine;Phenserine,(3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol5-(N-phenylcarbamate);(-)-N-PHENYLCARBAMOYLESEROLINE;(-)-phenserine;(-)-phenylcarbamoyleseroline;(3aS)-1,3 a,8-trimethyl-1,2,3,3 a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate;(3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol5-(N-phenylcarbamate);(3as-cis)-amate(ester;3-b)indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo(phenylcarb;(−)-N-Phenylcarbamoyleseroline;1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester);(-)-Eseroline phenylcarbamate;(-)-Phenserine
Cas No.	101246-66-6
分子式	C₂₀H₂₃N₃O₂
分子量	337.42
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	Phenserine ((-)-Eseroline phenylcarbamate) 是 Physostigmine 的衍生物，是一种有效的，非竞争性，长效和选择性的 AChE 抑制剂。Phenserine 可减少 β-淀粉样蛋白前体蛋白 (APP) 和 β-淀粉样肽 (Aβ) 的形成。Phenserine 可改善认知能力并减轻阿尔茨海默氏病的进展。
生物活性	Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimers disease.
性状	Solid
IC50 & Target[1][2]	AChE; β-amyloid precursor protein; β-amyloid peptide
体外研究(In Vitro)	Phenserine (1-25 μM; 48 hours; CHO APP751SW cells) treatment CHO APP751SW cell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis-tbl">
体内研究(In Vivo)	Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Klein J. Phenserine. Expert Opin Investig Drugs. 2007 Jul;16(7):1087-97. [2]. Asuni AA, et al. Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol. 2014 May;75(5):684-99. [3]. Janas AM, et al. The cholinesterase inhibitor, phenserine, improves Morris wate

溶解度数据	In Vitro: DMSO : 200 mg/mL (592.73 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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