Protriptyline hydrochloride|1225-55-4|(盐酸普罗替林)-陌孚医药/Medlife

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Protriptyline hydrochloride (Synonyms: 盐酸普罗替林)

目录号: PL05438 纯度: ≥99%

CAS No. :1225-55-4

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中文名称	Protriptyline hydrochloride
中文别名	盐酸普罗替林;盐酸普洛替林;N-甲基-5H-二苯并[a,d]环庚烯-5-丙胺盐酸盐;3,3'-二甲基-5,5'-二叔丁基联苯醌;普罗替林盐酸盐;普罗替林盐酸盐标准品;盐酸普罗替林 USP标准品;盐酸盐普罗替林标准品
英文名称	Protriptyline hydrochloride
英文别名	Protriptyline Hydrochloride;5H-Dibenzo[a,d]cycloheptene-5-propanamine,N-methyl-, hydrochloride (1:1);Protriptyline (hydrochloride);Protriptyline HCl;PROTRIPTYLINE HCL, USP STANDARD;Protriptyline Hydroc;Protriptyline hydrochloride solution;PROTRIPTYLINE HCL USP;N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine hydrochloride
Cas No.	1225-55-4
分子式	C₁₉H₂₁N^.HCl
分子量	299.84
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Protriptyline hydrochloride 是一种三环结构的抗抑郁试剂 (TCA)，含有一个仲胺，可以用于抑郁和 ADHD 的相关研究。与其他抗抑郁试剂相比是独一无二的，Protriptyline是倾向于使动物精力充沛激励作用，并且有时用于嗜睡症的相关研究。

生物活性

Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.

性状

Solid

体外研究(In Vitro)

Protriptyline hydrochloride (0-70 μM; 24 hours; PC3 cells) causes cytotoxicity in PC3 cells. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Cytotoxicity AssayCell Li

体内研究(In Vivo)

Protriptyline hydrochloride (10 mg/kg; i.p.; for 21 days; rat model of AD) improves spatial learning and retention memory in STZ treated rats. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Bansode SB, et, al. Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimers disease. PLoS One. 2014 Aug 20;9(8):e105196.
[2]. Chang HT, et, al. The mechanism of protriptyline-induced Ca2+ movement and non-Ca2+-triggered cell death in PC3 human prostate cancer cells. J Recept Signal Transduct Res. 2015;35(5):429-34.

溶解度数据	In Vitro: DMSO : 250 mg/mL (833.78 mM; Need ultrasonic)H₂O : 100 mg/mL (333.51 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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