Hemicholinium 3|312-45-8|(Hemicholinium dibromide)-陌孚医药/Medlife

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Hemicholinium 3 (Synonyms: Hemicholinium dibromide)

目录号: PL05577 纯度: ≥99%

CAS No. :312-45-8

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中文名称	Hemicholinium 3
中文别名	半胆碱基-3;密胆碱 3
英文名称	Hemicholinium 3
英文别名	Morpholinium,2,2'-[1,1'-biphenyl]-4,4'-diylbis[2-hydroxy-4,4-dimethyl-, bromide (1:2);2-[4-[4-(2-hydroxy-4,4-dimethylmorpholin-4-ium-2-yl)phenyl]phenyl]-4,4-dimethylmorpholin-4-ium-2-ol,dibromide;Hemicholinium-3;EINECS 206-227-3;HC-3;Hemicholine;hemicholinium;HEMICHOLINIUM 3;Hemicholinium 3 dibromide;Hemicholinium bromide;Hemicholinium dibromide;Hemicholinium-3 bromide;2,2′-(4,4′-Biphenylene)bis(2-hydroxy-4,4-dimethylmorpholinium bromide)
Cas No.	312-45-8
分子式	C₂₄H₃₄N₂O₄+₂^.₂[Br-]
分子量	574.35
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Hemicholinium 3 是一种竞争性的高亲和力胆碱转运蛋白 (HACU) 抑制剂，K_i 值为 25 nM。Hemicholinium 3抑制乙酰胆碱 (ACh)的合成和释放，用作一种神经肌肉阻滞剂。Hemicholinium 3 抑制Epibatidine诱发的收缩和 [³H] 乙酰胆碱释放，IC₅₀ 分别为 897 nM 和 693 nM。
生物活性	Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU) with a K i value of 25 nM. Hemicholinium 3, a neuromuscular blocking agent which inhibits the synthesis and the release of acetylcholine (ACh). Hemicholinium 3 inhibits the Epibatidine-evoked contraction and [H]acetylcholine release with IC50s of 897 nM and 693 nM, respectively.
性状	Solid
体外研究(In Vitro)	Hemicholinium 3 (HC-3) inhibits the presynaptic nicotinic acetylcholine receptors of myenteric neurons. HC-3 inhibits nAChRs located on the terminal region of myenteric neurons of guinea-pig longitudinal muscle strip preparation. Hemicholinium 3 (HC-3) inhibits[H]choline uptake with the Ki value of 13.3 μM in NCI-H69 cells. HC-3 (1 mM) significantly inhibits cell viability and increases caspase-3/7 activity in NCI-H69 cells. Hemicholinium 3 (Hemicholinium-3) inhibits sodium dependent high affinity choline uptake (IC50=18 nM). In vivo： has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Hemicholinium-3 impairs spatial learning. HC-3 (2.5, 5.0 μg/rat/ICV; 1 h before training) dose dependently impairs spatial learning. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. PATRICE GUYENET, et al. Inhibition by Hemicholinium-3 of [C] Acetylcholine Synthesis and [H] Choline High-Affinity Uptake in Rat Striatal Synaptosomes.Molecular Pharmacology September 1973, 9 (5) 630-639. [2]. Péter Mandl, et al. Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons. Neurochem Int. 2006 Sep;49(4):327-33.

溶解度数据	In Vitro: H₂O : 33.33 mg/mL (58.03 mM; Need ultrasonic)配制储备液

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