您当前的位置：

ZL006

目录号: PL01071 纯度: ≥99%

ZL006 是 nNOS/PSD-95 相互作用的抑制剂，可抑制 nMDA receptor 诱导的一氧化氮的合成。

CAS No. :1181226-02-7

商品编号	规格	价格	会员价
PL01071-5mg	5mg	¥332.00	请登录
PL01071-10mg	10mg	¥483.00	请登录
PL01071-25mg	25mg	¥985.00	请登录
PL01071-50mg	50mg	¥1585.00	请登录
PL01071-100mg	100mg	¥2785.00	请登录
PL01071-200mg	200mg	¥3885.00	请登录
PL01071-500mg	500mg	询价	询价
PL01071-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1237.00	请登录
PL01071-1 mL x 10 mM (in DMSO)		¥378.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	ZL006
中文别名	ZL006
英文名称	ZL006
英文别名	ZL006;ZL-006;4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid;4-(3,5-dichloro-2-hydroxy-benzylamino)-2-hydroxybenzoic acid;BCP32613;BDBM50496620;ZL006, >=98% (HPLC);J3.550.774D;4-(3,5-Dichloro-2-hydroxybenzylamino)-2-hydroxybenzoic acid;4-[(3,5-dichloro-2-hydroxyphenyl)methylamino]-2-hydroxybenzoic acid
Cas No.	1181226-02-7
分子式	C₁₄H₁₁Cl₂NO₄
分子量	328.15
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	ZL006 是 nNOS/PSD-95 相互作用的抑制剂，可抑制 nMDA receptor 诱导的一氧化氮的合成。

产品详情	ZL006 是 nNOS/PSD-95 相互作用的抑制剂，可抑制 nMDA receptor 诱导的一氧化氮的合成。
生物活性	ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis.
性状	Solid
体外研究(In Vitro)	ZL006 presents little cytotoxicity, and a growth inhibition of BCECs is not found at low concentration of 0.001, 0.01, 0.1, 1 and 10 μg/mL. The cytotoxicity of T7-P-LPs/ZL006 is significantly enhanced at the concentration of 10 μg/mL. Cellular uptake of ZL006 loads P-LPs and T7-P-LPs after incubation for 0.5 h at the concentrations range from 100 μg/mL to 600 μg/mL in BCECs. ZL006 does not inhibit the nNOS-PDZ/PSD-95-PDZ interaction, or perturb the nNOS β-finger. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Compared with P-LPs/ZL006 and free ZL006, T7-P-LPs/ZL006 exhibits a significant increase of drug accumulation in the brain tissue due to its better brain targeting delivery. Compared with free ZL006, P-LPs/ZL006 and T7-P-LPs/ZL006 exhibit a significant decrease of drug accumulation in the liver and kidney. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651. [2]. Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.

溶解度数据	In Vitro: DMSO : ≥ 29 mg/mL (88.37 mM)H₂O : < 0.1 mg/mL (insoluble)

搜索质检报告(COA)

产品使用指南

Data Sheet

[1]. Wang Z, et al. Enhanced anti-ischemic stroke of ZL006 by T7-conjugated PEGylated liposomes drug delivery system. Sci Rep. 2015 Jul 29;5:12651.
[2]. Bach A, et al. Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions. Sci Rep. 2015 Jul 16;5:12157.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

ZL006

相关产品

The molarity calculator equation

The dilution calculator equation