Purvalanol A|212844-53-6|(NG-60)-陌孚医药/Medlife

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Purvalanol A (Synonyms: NG-60)

目录号: PL14915 纯度: ≥98%

CAS No. :212844-53-6

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PL14915-200mg	200mg	询价	询价
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PL14915-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1059.00	请登录

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中文名称	Purvalanol A
中文别名	PURVALANOL A 抑制剂;PURVALANOL A
英文名称	Purvalanol A
英文别名	(R)-2-((6-((3-Chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol;(2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol;(R)-Purvalanol A;1-Butanol,2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-,(2R)-;NG-60;PURVALANOL A;2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-60;P01;Purv;2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine;NG 60;6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine;PURVALANOLA;C19H25ClN6O;(2R)-2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol;2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL;(2R)-2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1;Purvalanol A
Cas No.	212844-53-6
分子式	C₁₉H₂₅ClN₆O
分子量	388.89
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Purvalanol A 是一种有效的 CDK 抑制剂，对 cdc2-cyclin B，cdc2-cyclin B，cdk2-cyclin E，cdk4-cyclin D1 和 cdk5-p35 的 IC₅₀ 值分别为 4，70，35，850 和 75 nM。
生物活性	Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC 50 s of 4, 70, 35, 850, 75 nM, resepctively.
性状	Solid
IC50 & Target[1][2]	cdc2-cyclin B 4 nM (IC50) cdk2-cyclin E 35
体外研究(In Vitro)	Purvalanol A inhibits cdc28 (S. cerevisiae) and erk1 with IC50s of 80 and 9000 nM. Purvalanol A shows inhibitory activities against the NCI panel of 60 human tumor cell lines, with average GI50 of 2 μM; two cell lines show an -20-fold increase in sensitivity to purvalanol A: the KM12 colon cancer cell line with a GI50 of 76 nM and the NCI-H522 non–small cell lung cancer cell line with a GI50 of 347 nM. Purvalanol A is a 2.5-fold more potent inhibitor of CDK2, but also inhibits DYRK1A potently and a number of other protein kinases in the low micromolar range. Purvalanol A inhibits MKK1, MAPK2/ERK2, JNK/SAPK1c with IC50s of 80, 26, 84 μM. Purvalanol A selectively inhibits the phosphorylation of cellular proteins. Purvalanol A prevents the increases of the contents of cyclins D and E during serum-induced G1 phase progression. Purvalanol
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Gray NS, et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. [2]. Bain J, et al. The specificities of protein kinase inhibitors: an update. Biochem J. 2003 Apr 1;371(Pt 1):199-204. [3]. Villerbu N, et al. Cellular effects of pu

溶解度数据	In Vitro: DMSO : ≥ 50 mg/mL (128.57 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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