Pantoprazole sodium|138786-67-1|(泮托拉唑钠; BY1023 sodium; SKF96022 sodium)-陌孚医药/Medlife

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Pantoprazole sodium (Synonyms: 泮托拉唑钠; BY1023 sodium; SKF96022 sodium)

目录号: PL14916 纯度: ≥99%

CAS No. :138786-67-1

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中文名称	Pantoprazole sodium
中文别名	泮托拉唑钠;5-二氟甲氧基-2-[(3,4-二甲氧基-2-吡啶基)甲基]亚硫酰基-1H-苯骈咪唑钠盐;巴毒磷;丁烯磷;潘托拉唑钠;泮托拉唑钠盐;萘甲唑啉盐酸盐;潘托拉唑钠及其杂质标准品;泮托拉唑钠标准品;泮托拉唑钠一水;泮托拉唑钠一水合物;泮托拉唑钠一水物;泮托拉唑钠杂质;洋艾素
英文名称	Pantoprazole sodium
英文别名	Pantoprazole Sodium;5-(DIFLUOROMETHOXY)-2-[[(3,4-DIMETHOXY-2-PYRIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE;5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1h-benzimidazole sodium;EUPANTOL;PANTECTA;PANTOPRAZOLE SODIUM HYDRATE;PANTOPRAZOLE, SODIUM SALT;ANTOZOL;1h-benzimidazole,5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sul;5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzi;midazolesodium;PANTOPRAZOLE SODIUM MONOHYDRATE;Pantoprazole sodium(factory standard);5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridynyl)methyl]-1H-benzimidazol-1-ium sodium salt;Controloc;Pantoloc;Protonix;Sodium pantoprazole;SKF96022 sodium;Pantoprazole;Protonix sodium;Zurcal;Protium;PANTOPRAZOLE SODIUM SALT;Protonix IV;Pantoprazole Sodium [USAN];Pantozol Control;DSSTox_RID_80123;DSSTox_CID_24215;DSSTox_GSID_44215;C16H14F2N3NaO4S;5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole sodium;Anagastra;Pantorc;Inipomp;Ulcotenal;Peptazol;Nolpaza;Citrel;Rifun;Apton;Protonix I.V;sodium;5-(difluoromethoxy)-2;Pantoprazole sodium
Cas No.	138786-67-1
分子式	C₁₆H₁₄F₂N₃NaO₄S
分子量	405.35
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Pantoprazole sodium (BY1023 sodium) 是一种具有口服活性的，有效质子泵 (proton pump) 抑制剂 (PPI)。Pantoprazole sodium 是一种取代的苯并咪唑，是一种有效的 H⁺/K⁺-ATPase 抑制剂，IC₅₀ 为 6.8 μM。Pantoprazo sodium 可以改善 pH 值稳定性，并具有抗分泌，抗溃疡的作用。Pantoprazo sodium 联合阿霉素 (Doxorubicin; HY-15142) 可显着增加肿瘤生长延迟。

生物活性

Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI). Pantoprazole sodium, a substituted benzimidazole, is a potent H/K-ATPase inhibitor with an IC 50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142).

性状

Solid

IC50 & Target[1][2]

proton pump

体外研究(In Vitro)

Pantoprazole sodium (BY1023 sodium; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells.
Pantoprazole sodium can block exosome release. Pantoprazole sodium inhibits the activity of V-H-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Pantoprazole sodium (BY1023 sodium; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin.
Pantoprazole sodium (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Krupa J Patel, et al. Use of the proton pump inhibitor pantoprazole to modify the distribution and activity of doxorubicin: a potential strategy to improve the therapy of solid tumors. Clin Cancer Res. 2013 Dec 15;19(24):6766-76.
[2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (246.70 mM)H₂O : 3.85 mg/mL (9.50 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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