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C75

目录号: PL14892 纯度: ≥99%

C75 是合成的脂肪酸合成酶 (FASN) 抑制剂。C75 抑制前列腺癌细胞 PC3 的 IC50 值为 35 μM。C75 是有效的 CPT1A 激活剂。

CAS No. :218137-86-1

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中文名称	C75
中文别名	3-羧基-4-辛基-2-亚甲基丁内酯
英文名称	C75
英文别名	3-Furancarboxylic acid,tetrahydro-4-methylene-2-octyl-5-oxo-;3-CARBOXY-4-OCTYL-2-METHYLENEBUTYROLACTONE;C 75 (4-METHYLENE-2-OCTYL-5-OXO-TETRAHYDRO-FURAN-3-CARBOXYLIC ACID);4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid;4-Methylene-2-octyl-5-oxo-tetrahydro-furan-3-carboxylic acid;C 75;C-75;C75
Cas No.	218137-86-1
分子式	C₁₄H₂₂O₄
分子量	254.32
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	C75 是合成的脂肪酸合成酶 (FASN) 抑制剂。C75 抑制前列腺癌细胞 PC3 的 IC50 值为 35 μM。C75 是有效的 CPT1A 激活剂。

产品详情	C75 是合成的脂肪酸合成酶 (FASN) 抑制剂。C75 抑制前列腺癌细胞 PC3 的 IC₅₀ 值为 35 μM。C75 是有效的 CPT1A 激活剂。
生物活性	C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC 50 of 35 μM. C75 is a potent CPT1A activator.
性状	Solid
IC50 & Target[1][2]	IC50: 35 μM (PC3 cell)
体外研究(In Vitro)	C75 inhibits PC3 cell growht with an IC50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy. [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7. [3]. Gao S, et al. Effe

溶解度数据	In Vitro: DMSO : ≥ 83.3 mg/mL (327.54 mM)H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

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[1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.
[2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.
[3]. Gao S, et al. Effe

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

C75

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