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FGH10019

目录号: PL11604 纯度: ≥99%

FGH10019 是一种固醇调节元件结合蛋白 (SREBP) 抑制剂，IC50 值为 1 μM。

CAS No. :1046045-61-7

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中文名称	FGH10019
中文别名	FGH10019
英文名称	FGH10019
英文别名	FGH10019;FGH-10019;N-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenyl)methanesulfonamide;BDBM50351538;N-[4-[2-(2-propyl-4-pyridyl)thiazol-4-yl]phenyl]methanesulfonamide;N-[4-[2-(2-propylpyridin-4-yl)-1,3-thiazol-4-yl]phenyl]methanesulfonamide;METHANESULFONAMIDE,N-[4-[2-(2-PROPYL-4-PYRIDINYL)-4-THIAZOLYL]PHENYL]-
Cas No.	1046045-61-7
分子式	C₁₈H₁₉N₃O₂S₂
分子量	373.49
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	FGH10019 是一种固醇调节元件结合蛋白 (SREBP) 抑制剂，IC50 值为 1 μM。

产品详情	FGH10019 是一种固醇调节元件结合蛋白 (SREBP) 抑制剂，IC₅₀ 值为 1 μM。
生物活性	FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC 50 of 1 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 1 μM (SREBP)
体外研究(In Vitro)	Treatment of the CHO-K1 cells with analog FGH10019 decreases the percentage of the mature form of SREBP-2 (68 kDa) at lower concentrations than treatment with fatostatin. Densitometric analysis of the gels indicates that the IC50 of analog FGH10019 is approximately 1 μM, which is 5-10 times lower than the IC50 of fatostatin (appr 10 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	FGH10019-treated chow is fed at a dose rate calculated to provide about 0.7 mg analog FGH10019 per day, at about 23 mg/kg body weight, to 5-wk-old male ob/ob mice weighing an average of appr 30 g. After 8 wk on the analog 24-treated chow, the mice gain 8-9 % less weight than control mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Kamisuki S, et al. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14;54(13):4923-7.

溶解度数据	In Vitro: DMSO : ≥ 38 mg/mL (101.74 mM)配制储备液

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[1]. Kamisuki S, et al. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14;54(13):4923-7.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

FGH10019

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